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The Annals of Thoracic Surgery, Vol 39, 212-217, Copyright © 1985 by The Society of Thoracic Surgeons
H van Velzen-Blad, YJ Dijkstra, CJ Heijnen, GA Schurink, BJ Zegers and RE Ballieux
In 47 patients undergoing open-heart surgical procedures, the influence of
cardiopulmonary bypass (CPB) on lymphocyte function was investigated by
studying in vitro the mitogen responses of lymphocytes in whole blood
cultures. Subnormal mitogen responses before operation that likely resulted
from dexamethasone medication were found in half of the patients studied.
During operation, changes in phytohemagglutinin responses were uniform in a
group of 23 patients. No significant effect of anesthesia and operation was
observed until the patients were heparinized (i.e., before CPB). At the end
of operation, the phytohemagglutinin response was below normal. In a group
of 24 other patients, postoperative mitogen responses were studied. A
tendency toward restoration of mitogen responses was observed in most
patients the first morning after operation. However, no uniform pattern of
normalization of mitogen responses was found. In an attempt to relate
postoperative mitogen responses to trauma resulting from CPB, we observed
that perioperative (in comparison with postoperative) administration of
blood coincided with a significantly higher incidence of subnormal
phytohemagglutinin and pokeweed mitogen responses on postoperative day 1.
No correlation between laboratory data and clinical findings could be
established.
ARTICLES
Cardiopulmonary bypass and host defense functions in human beings: II. Lymphocyte function
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