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Ann Thorac Surg 1985;39:207-211
© 1985 The Society of Thoracic Surgeons

Articles

Cardiopulmonary Bypass and Host Defense Functions in Human Beings: I. Serum Levels and Role of Immunoglobulins and Complement in Phagocytosis

Heleen van Velzen-Blad, M.Sc.*, Y.J. Dijkstra, M.D., G.A. Schurink, M.D., H.A. Verbrugh, Ph.D., J. Verhoef, Ph.D., B.J.M. Zegers, Ph.D., R.E. Ballieux, Ph.D.

From the University Children's Hospital "Het Wilhelmina Kinderziekenhuis"; the Department of Clinical Bacteriology, Laboratory for Microbiology; and the University Hospital, Utrecht; and the St. Antonius Hospital, Nieuwegein, The Netherlands

Accepted for publication May 15, 1984.

* Address reprint requests to Ms. van Velzen-Blad, Department of Immunology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands

In patients undergoing open-heart surgical procedures, the serum levels of immunoglobulins and complement were determined as well as the functional capacity of these defense proteins as opsonins to facilitate phagocytosis by polymorphonuclear leukocytes. A considerable decrease in serum levels of the proteins studied was found after cardiopulmonary bypass (CPB). As a result, the opsonic capacity of post-CPB plasma was diminished. After correction for hemodilution, however, no difference between pre- and post-CPB plasma, as measured by the activity of thermolabile (e.g., complement C3) and thermostabile (e.g., immunoglobulin IgG) opsonins, could be demonstrated. It is concluded that CPB causes a quantitative but no functional decrease in levels of IgG and C3.




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