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The Annals of Thoracic Surgery, Vol 39, 165-169, Copyright © 1985 by The Society of Thoracic Surgeons
Y Monden, K Nakahara, S Iioka, S Nanjo, K Ohno, Y Fujii, J Hashimoto, Y Kitagawa, A Masaoka and Y Kawashima
Factors influencing the recurrence or persistence of thymoma after therapy
were investigated in 127 patients with thymoma, including 75 with thymoma
and myasthenia gravis. The rate of recurrence or persistence was 19% (24 of
127 patients) overall, 11% (8 of 75 patients) in myasthenic thymoma, and
31% (16 of 52 patients) in nonmyasthenic thymoma. The more advanced the
clinical stage, the higher the rate of recurrence or persistence. The
recurrence/persistence rate for patients with the same clinical stage was
higher in those with nonmyasthenic thymoma (8% in Stage I, 11% in Stage II,
36% in Stage III, and 75% in Stage IV) than in those with myasthenic
thymoma (0 in Stage I, 13% in Stage II, 18% in Stage III, and 20% in Stage
IV). The prognosis for patients having subtotal resection of tumor was good
in myasthenic thymoma (recurrence/persistence rate, 17%) in contrast with
nonmyasthenic thymoma (recurrence/persistence rate, 78%). These results
suggest that nonmyasthenic thymoma is more malignant than myasthenic
thymoma. Postoperative radiotherapy was effective in preventing the
recurrence or persistence of thymoma after therapy.
ARTICLES
Recurrence of thymoma: clinicopathological features, therapy, and prognosis
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