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The Annals of Thoracic Surgery, Vol 38, 592-600, Copyright © 1984 by The Society of Thoracic Surgeons
AV Govier, JG Reves, RD McKay, RB Karp, GL Zorn, RB Morawetz, LR Smith, M Adams and AM Freeman
In this study we examined the relationship of regional cerebral blood flow
(CBF) to mean arterial pressure, systemic blood flow, partial pressure of
arterial carbon dioxide (PaCO2), nasopharyngeal temperature, and hemoglobin
during hypothermic nonpulsatile cardiopulmonary bypass (CPB). Regional CBF
was determined by clearance of xenon 133 in 67 patients undergoing coronary
bypass grafting procedures. There was a significant decrease in regional
CBF (55% decrease) during CPB, with nasopharyngeal temperature and PaCO2
being the only two significant factors (p less than 0.05). In a subgroup of
10 patients, variation of pump flow between 1.0 and 2.0 L/min/m2 did not
significantly affect regional CBF. We conclude that cerebral autoregulation
is retained during hypothermic CPB. Under the usual conditions of CPB,
variations in flow and pressure are not associated with important
physiological or detrimental clinical affects.
ARTICLES
Factors and their influence on regional cerebral blood flow during nonpulsatile cardiopulmonary bypass
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