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James W. Mackenzie
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Glenn E. Sisler
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Ann Thorac Surg 1984;38:133-139
© 1984 The Society of Thoracic Surgeons

Articles

Urinary Catabolites of Ribonucleic Acid as Cancer Markers: A Preliminary Report of Their Use in Patients with Lung Cancer

James W. Mackenzie, M.D.*, Ralph J. Lewis, M.D., Glenn E. Sisler, M.D., Win Lin, Ph.D., John Rogers, M.D., Irwin Clark, Ph.D.

Department of Surgery, University of Medicine and Dentistry of New Jersey-Rutgers Medical School, New Brunswick, NJ

Accepted for publication February 21, 1984.

* Address reprint requests to Dr. Mackenzie, Department of Surgery, UMDNJ–Rutgers Medical School, CN 19, New Brunswick, NJ 08903

Rats with aflatoxin-B1-induced hepatomas and dimethylnitrosamine-induced nephroblastomas excreted greater than normal amounts of urinary modified nucleosides and bases, catabolites of ribonucleic acid (RNA). Although both neoplasms caused increased excretions of the same catabolites, their quantitative profiles differed, suggesting that it may be possible to distinguish between tumors. Rats with transplanted tumors (e.g., hepatomas and osteogenic sarcomas) did not excrete elevated levels of urinary RNA catabolites until approximately 20 days after transplantation despite rapid growth of the tumor for the first 15 days. These data suggest that the source of the elevated levels of these excretory products may be the host's tissue RNA. Preliminary studies in human beings with lung cancer showed marked elevation of one or more urinary RNA catabolites. Resection of the diseased tissue in 2 patients caused a drop in levels. The measurement of urinary RNA catabolites may be useful in the diagnosis, prognosis, and evaluation of therapy in patients with lung cancer.






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