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Ann Thorac Surg 1984;38:46-52
© 1984 The Society of Thoracic Surgeons

Articles

Myasthenia Gravis with Thymoma: Analysis of and Postoperative Prognosis for 65 Patients with Thymomatous Myasthenia Gravis

Yasumasa Monden, M.D.*, Kazuya Nakahara, M.D., Katsumi Kagotani, M.D., Yoshitaka Fujii, M.D., Akira Masaoka, M.D., Yasunaru Kawashima, M.D.

First Department of Surgery, Osaka University Medical School, Osaka, Japan

Accepted for publication October 28, 1983.

* Address reprint requests to Dr. Monden, First Department of Surgery, Osaka University Medical School, 1-1-50, Fukushima, Fukushima-ku, Osaka 553, Japan

Sixty-five patients with thymomatous myasthenia gravis were investigated. Thymomas were present in 44% of the male patients and 19% of the female patients with myasthenia gravis. The incidence of thymomatous disease in male patients was higher than in female patients in all age groups. Eighty percent of men more than 50 years old and women more than 60 years old had myasthenia gravis with thymoma. Germinal center formation in the thymus of patients with thymomatous myasthenia gravis was positive in 91% and was high grade.

The prognosis for patients undergoing extended thymectomy of thymomatous myasthenia gravis was significantly better than in those having transsternal simple thymectomy, but it was worse than the prognosis for patients with nonthymomatous myasthenia gravis. No increase in the rate of remission or palliation was seen one year after thymectomy. It is concluded that early thymectomy is effective in control of myasthenia gravis in thymomatous myasthenia gravis.




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