HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guidoin, R. Articles by Gosselin, C. Search for Related Content PubMed PubMed Citation Articles by Guidoin, R. Articles by Gosselin, C.

Ann Thorac Surg 1984;37:457-465
© 1984 The Society of Thoracic Surgeons

---

Articles

Albumin Coating of a Knitted Polyester Arterial Prosthesis: An Alternative to Preclotting

From the Departments of Surgery and Pathology, Laval University and St-François d'Assise Hospital, Quebec, PQ, Canada, Bard Implants Division, C.R. Bard, Inc., Billerica, MA, Department of Clothing and Textiles, University of Manitoba, Winnipeg, Man, Canada, and the Laboratoire de Technologie Enzymatique, University of Technology, Compiègne, France

Accepted for publication November 10, 1983.

^* Address reprint requests to Dr. Guidoin, Laboratory of Experimental Surgery, Pavillon Agriculture-Services, Laval University, Quebec, PQ, Canada G1K 7P4

Coating a knitted polyester arterial prosthesis with cross-linked albumin fills the interstices of the graft and relieves the surgeon of the necessity to preclot. This is of particular value in patients whose blood clotting properties are hypercoagulable, or hypocoagulable. In addition, such prostheses require less handling, which can lower the risk of bacteremic colonization and shorten the operative time. The in vivo behavior of the implanted albuminated prosthesis in the thoracic aorta of dogs is similar to that of preclotted grafts, although the sequences of early healing are different. The preclotted graft develops a continuous, thick thrombotic matrix on its luminal surface during the first 4 hours of implantation. Following the initiation of the fibrinolytic mechanism 24 to 48 hours postoperatively, this thrombotic deposit quickly recedes, leaving blood cells and platelets adhering here and there to the prosthetic surface. In comparison, the albuminated coating is not associated with major early thrombotic deposits. The albumin remains visible between the filaments during the first 2 weeks of implantation. Both treated and control grafts contain numerous thrombi on their inner surface after 1 to 2 weeks. After 1, 3, and 6 months, both implants are well encapsulated and present a glistening and continuous luminal surface. This excellent healing, however, can be compromised should the graft adhere too closely to the animal's lungs. After 6 months, the cleaned, explanted prosthesis shows a well-preserved textile structure. Because of the reduced risks of postoperative hemorrhage and acute thrombosis and the ease of preparation, handling, and suturing, we believe an albumin coating provides a desirable and viable alternative to preclotting polyester prostheses.

This article has been cited by other articles:

				W. Schmiedt, A. Neufang, E. Scholl, F. X. Schmid, and H. Oelert Immune Response to Gelatin- and Collagen-Impregnated Aortic Dacron Grafts: A Randomized Study Vascular and Endovascular Surgery, November 1, 1996; 30(6): 513 - 518. [Abstract] [PDF]

				T. V. How, R. Guidoin, and S. K. Young Engineering Design of Vascular Prostheses Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, June 1, 1992; 206(2): 61 - 71. [Abstract] [PDF]

				R. A. Jonas, F. J. Schoen, R. J. Levy, and A. R. Castaneda Biological Sealants and Knitted Dacron: Porosity and Histological Comparisons of Vascular Graft Materials with and without Collagen and Fibrin Glue Pretreatments Ann. Thorac. Surg., June 1, 1986; 41(6): 657 - 663. [Abstract] [PDF]