HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Shlomo Gabbay Uberto Bortolotti Robert W.M. Frater Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gabbay, S. Articles by Factor, S. M. Search for Related Content PubMed PubMed Citation Articles by Gabbay, S. Articles by Factor, S. M.

Ann Thorac Surg 1984;37:448-456
© 1984 The Society of Thoracic Surgeons

---

Articles

The Meadox Unicusp Pericardial Bioprosthetic Heart Valve: New Concept

From the Departments of Cardiothoracic Surgery and Pathology, Albert Einstein College of Medicine, Bronx, NY

^* Address reprint requests to Dr. Gabbay, Department of Cardiothoracic Surgery, Albert Einstein College of Medicine, 1825 Eastchester Rd, Bronx, NY 10461

To obtain a valve with better hemodynamic performance and longer durability than the currently available bioprostheses, a single-cusp pericardial xenograft has been developed. This valve has been tested extensively both in vitro, in a pulse duplicator and in a fatigue-testing system, and in vivo, in a series of dogs and sheep.

Hemodynamic studies showed improved hemodynamic performance compared with other biological and mechanical valves. Effective orifice areas were larger and performance indexes higher, especially in the small sizes. Accelerated fatigue testing showed durability significantly superior to that of other biological devices.

Animal experiments have established that the single cusp remains pliable even after more than two years of insertion. There is a low incidence of calcification and good preservation of the collagen matrix.

This preliminary experience demonstrates that the unicusp pericardial xenograft has superior hemodynamics, increased resistance to fatigue-induced lesions, and a low incidence of calcification. These results might indicate an extended in vivo durability for this device.

This article has been cited by other articles:

				U. Bortolotti, P. Ius, G. Thiene, M. Minarini, A. Milano, C. Valfre, E. Talenti, M. Valente, and A. Mazzucco The meadox-gabbay pericardial xenograft: Failure of the unicusp principle Ann. Thorac. Surg., November 1, 1992; 54(5): 952 - 957. [Abstract] [PDF]

				S. Gabbay Invited commentary Ann. Thorac. Surg., November 1, 1992; 54(5): 957 - 958. [PDF]