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Ann Thorac Surg 1984;37:359-364
© 1984 The Society of Thoracic Surgeons
Departments of Pathology, Medicine, and Cardiovascular Surgery, Veterans Administration Medical Center and the University of New Mexico School of Medicine, and United Blood Services, Albuquerque, NM
Accepted for publication September 23, 1983.
* Address reprint requests to Dr. Simon, Associate Professor, Pathology Department, University of New Mexico School of Medicine, Albuquerque, NM 87131
Prophylactic administration of platelet concentrates to patients undergoing their first cardiopulmonary bypass operation (coronary artery bypass grafting or uncomplicated valve replacement) was evaluated in a controlled randomized study of 28 patients. Four units of platelet concentrates administered at the end of bypass prevented prolongation of the bleeding time seen in patients not receiving platelets. However, chest tube blood loss, transfusion requirements, and clinical outcome were not improved. Moreover, thrombocytopenia and prolongation of bleeding time did not correlate with blood loss or transfusion needs. Mild thrombocytopenia (to 58,000 platelets per microliter) and transient platelet dysfunction after bypass do not require administration of platelet concentrates, and prophylactic use of this blood component in the surgical setting of bypass is not indicated.
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