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The Annals of Thoracic Surgery, Vol 37, 359-364, Copyright © 1984 by The Society of Thoracic Surgeons
TL Simon, BF Akl and W Murphy
Prophylactic administration of platelet concentrates to patients undergoing
their first cardiopulmonary bypass operation (coronary artery bypass
grafting or uncomplicated valve replacement) was evaluated in a controlled
randomized study of 28 patients. Four units of platelet concentrates
administered at the end of bypass prevented prolongation of the bleeding
time seen in patients not receiving platelets. However, chest tube blood
loss, transfusion requirements, and clinical outcome were not improved.
Moreover, thrombocytopenia and prolongation of bleeding time did not
correlate with blood loss or transfusion needs. Mild thrombocytopenia (to
58,000 platelets per microliter) and transient platelet dysfunction after
bypass do not require administration of platelet concentrates, and
prophylactic use of this blood component in the surgical setting of bypass
is not indicated.
ARTICLES
Controlled trial of routine administration of platelet concentrates in cardiopulmonary bypass surgery
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