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The Annals of Thoracic Surgery, Vol 37, 243-248, Copyright © 1984 by The Society of Thoracic Surgeons
WN Wicomb, DK Cooper, D Novitzky and CN Barnard
Four patients have undergone heterotopic heart transplantation with donor
hearts stored by a portable hypothermic perfusion system. Total ischemic
periods ranged from 6 hours 55 minutes to 16 hours 50 minutes. One heart,
transplanted into a patient who had acutely rejected a previous graft,
suffered accelerated, irreversible, acute rejection within five days,
associated with strong antibody formation; donor heart function was never
good. In the 3 remaining patients, donor heart function was good after
initially being poor for a few hours in 2 patients. One patient died of
long-term rejection after 6 months and 1 of tuberculous meningitis after 10
months; 1 remains alive at 15 months. Neither preservation of the donor
heart for periods in excess of approximately 4 hours nor the use of
continuous hypothermic perfusion as a method of preservation appears to
have been reported previously in the context of the clinical situation.
ARTICLES
Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system
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