HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wicomb, W. N. Articles by Barnard, C. N. Search for Related Content PubMed PubMed Citation Articles by Wicomb, W. N. Articles by Barnard, C. N.

The Annals of Thoracic Surgery, Vol 37, 243-248, Copyright © 1984 by The Society of Thoracic Surgeons

ARTICLES

Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system

WN Wicomb, DK Cooper, D Novitzky and CN Barnard

Four patients have undergone heterotopic heart transplantation with donor hearts stored by a portable hypothermic perfusion system. Total ischemic periods ranged from 6 hours 55 minutes to 16 hours 50 minutes. One heart, transplanted into a patient who had acutely rejected a previous graft, suffered accelerated, irreversible, acute rejection within five days, associated with strong antibody formation; donor heart function was never good. In the 3 remaining patients, donor heart function was good after initially being poor for a few hours in 2 patients. One patient died of long-term rejection after 6 months and 1 of tuberculous meningitis after 10 months; 1 remains alive at 15 months. Neither preservation of the donor heart for periods in excess of approximately 4 hours nor the use of continuous hypothermic perfusion as a method of preservation appears to have been reported previously in the context of the clinical situation.

This article has been cited by other articles:

				M. J. Collins, S. L. Moainie, B. P. Griffith, and R. S. Poston Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool. Eur. J. Cardiothorac. Surg., August 1, 2008; 34(2): 318 - 325. [Abstract] [Full Text] [PDF]

				R. S. Poston, J. Gu, D. Prastein, F. Gage, J. W. Hoffman, M. Kwon, A. Azimzadeh, R. N. Pierson III, and B. P. Griffith Optimizing Donor Heart Outcome After Prolonged Storage With Endothelial Function Analysis and Continuous Perfusion Ann. Thorac. Surg., October 1, 2004; 78(4): 1362 - 1370. [Abstract] [Full Text] [PDF]

				A. Khoynezhad, Z. Jalali, and A. J. Tortolani Apoptosis: Pathophysiology and therapeutic implications for the cardiac surgeon Ann. Thorac. Surg., September 1, 2004; 78(3): 1109 - 1118. [Abstract] [Full Text] [PDF]

				F. Kuhn-Regnier, J. H. Fischer, S. Jeschkeit, R. Switkowski, O. Bardakcioglu, R. Sobottke, and E. R. de Vivie Coronary oxygen persufflation combined with HTK cardioplegia prolongs the preservation time in heart transplantation Eur. J. Cardiothorac. Surg., January 1, 2000; 17(1): 71 - 76. [Abstract] [Full Text] [PDF]

				T. M. Aziz, M. I. Burgess, A. El-Gamel, C. S. Campbell, A. N. Rahman, A. K. Deiraniya, and N. A. Yonan Orthotopic cardiac transplantation technique: a survey of current practice Ann. Thorac. Surg., October 1, 1999; 68(4): 1242 - 1246. [Abstract] [Full Text] [PDF]

				D. K. Nickless, M. Rabinov, S. M. Richards, R. A.J. Conyers, and F. L. Rosenfeldt Continuous Perfusion Improves Preservation of Donor Rat Hearts: Importance of the Implantation Phase Ann. Thorac. Surg., May 1, 1998; 65(5): 1265 - 1272. [Abstract] [Full Text] [PDF]

				P. O. Daily, R. M. Adamson, B. H. Jones, W. P. Dembitsky, and R. J. Moreno-Cabral Comparisons of Methods of Myocardial Hypothermia for Cardiac Transplantation Ann. Thorac. Surg., February 1, 1996; 61(2): 679 - 683. [Abstract] [Full Text]

				D. Wheeldon Thoracic organ preservation Perfusion, July 1, 1991; 6(3): 191 - 202. [Abstract] [PDF]