HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Putnam, J. B. Articles by Rosenberg, S. A. Search for Related Content PubMed PubMed Citation Articles by Putnam, J. B., Jr Articles by Rosenberg, S. A.

The Annals of Thoracic Surgery, Vol 36, 516-523, Copyright © 1983 by The Society of Thoracic Surgeons

ARTICLES

Survival following aggressive resection of pulmonary metastases from osteogenic sarcoma: analysis of prognostic factors

JB Putnam Jr, JA Roth, MN Wesley, MR Johnston and SA Rosenberg

Between 1975 and 1982, 80 patients with osteogenic sarcoma were entered into prospective trials in the Surgery Branch of the National Cancer Institute. In 43 of these patients, pulmonary metastases developed as the initial site of recurrence, and 39 underwent one or more thoracotomies for resection of the disease. The actuarial five-year survival for the group of 43 patients with pulmonary metastases was 40%. Various prognostic factors were analyzed for their influence on survival after thoracotomy. Age, sex, location of primary tumor, tumor doubling time, and involvement of one or both lungs (bilaterality) were not significant in predicting survival. Prognostic factors that influenced survival, calculated by regression analysis, included the number of nodules on preoperative lung tomograms (negative correlation, p = 0.0004), disease-free interval (positive correlation, p = 0.0136), resectability (positive correlation, p = 0.002), and the number of metastases resected at thoracotomy (negative correlation, p = 0.0032). The presence of 3 nodules or less on preoperative full-lung linear tomography was found to be the single most useful preoperative prognostic factor. The application of these prognostic factors preoperatively may identify patients who will benefit optimally from thoracotomy.

This article has been cited by other articles:

				A. M. Parsons, E. K. Ennis, B. C. Yankaskas, L. A. Parker Jr, W. B. Hyslop, and F. C. Detterbeck Helical Computed Tomography Inaccuracy in the Detection of Pulmonary Metastases: Can It Be Improved? Ann. Thorac. Surg., December 1, 2007; 84(6): 1830 - 1836. [Abstract] [Full Text] [PDF]

				A. J. Poncelet, A. Lurquin, B. Weynand, Y. Humblet, P. Noirhomme, and on behalf of the 'Groupe d' Oncologie Thoracique D Prognostic factors for long-term survival in patients with thoracic metastatic disease: a 10-year experience Eur. J. Cardiothorac. Surg., February 1, 2007; 31(2): 173 - 180. [Abstract] [Full Text] [PDF]

				R. D. Loberg, C. J. Logothetis, E. T. Keller, and K. J. Pienta Pathogenesis and Treatment of Prostate Cancer Bone Metastases: Targeting the Lethal Phenotype J. Clin. Oncol., November 10, 2005; 23(32): 8232 - 8241. [Abstract] [Full Text] [PDF]

				B. Kempf-Bielack, S. S. Bielack, H. Jurgens, D. Branscheid, W. E. Berdel, G. U. Exner, U. Gobel, K. Helmke, G. Jundt, H. Kabisch, et al. Osteosarcoma Relapse After Combined Modality Therapy: An Analysis of Unselected Patients in the Cooperative Osteosarcoma Study Group (COSS) J. Clin. Oncol., January 20, 2005; 23(3): 559 - 568. [Abstract] [Full Text] [PDF]

				S. Ferrari, A. Briccoli, M. Mercuri, F. Bertoni, P. Picci, A. Tienghi, A. B. Del Prever, F. Fagioli, A. Comandone, and G. Bacci Postrelapse Survival in Osteosarcoma of the Extremities: Prognostic Factors for Long-Term Survival J. Clin. Oncol., February 15, 2003; 21(4): 710 - 715. [Abstract] [Full Text] [PDF]

				G. Friedel, U. Pastorino, R. J. Ginsberg, P. Goldstraw, M. Johnston, H. Pass, J. B. Putnam, and H. Toomes Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the international registry of lung metastases Eur. J. Cardiothorac. Surg., September 1, 2002; 22(3): 335 - 344. [Abstract] [Full Text] [PDF]

				H. Tsuchiya, Y. Kanazawa, M. E. Abdel-Wanis, N. Asada, S. Abe, K. Isu, T. Sugita, and K. Tomita Effect of Timing of Pulmonary Metastases Identification on Prognosis of Patients With Osteosarcoma: The Japanese Musculoskeletal Oncology Group Study J. Clin. Oncol., August 15, 2002; 20(16): 3470 - 3477. [Abstract] [Full Text] [PDF]

				B. K. Temeck, L. H. Wexler, S. M. Steinberg, L. L. McClure, M. A. Horowitz, and H. I. Pass Reoperative pulmonary metastasectomy for sarcomatous pediatric histologies Ann. Thorac. Surg., September 1, 1998; 66(3): 908 - 913. [Abstract] [Full Text] [PDF]

				B. K. Temeck, L. H. Wexler, S. M. Steinberg, L. L. McClure, M. Horowitz, and H. I. Pass Metastasectomy for Sarcomatous Pediatric Histologies: Results and Prognostic Factors Ann. Thorac. Surg., June 1, 1995; 59(6): 1385 - 1390. [Abstract] [Full Text]