HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chambers, D. J. Articles by Chayen, J. Search for Related Content PubMed PubMed Citation Articles by Chambers, D. J. Articles by Chayen, J.

Ann Thorac Surg 1983;36:306-313
© 1983 The Society of Thoracic Surgeons

---

Articles

The Effect of Ionized Calcium, pH, and Temperature on Bioactive Parathyroid Hormone during and after Open-Heart Operations

From the Departments of Heart Research (Surgical Cytochemistry), Max Rayne Institute, Cardiothoracic Surgery and Clinical Pathology, St. Thomas Hospital, and the Division of Cellular Biology, The Mathilda and Terence Kennedy Institute of Rheumatology, London, England

Accepted for publication November 30, 1982.

^* Address reprint requests to Dr. Chambers, Heart Research (Surgical Cytochemistry), Max Rayne Institute, St. Thomas Hospital, London SE1 7EH, England

Normal myocardial function is dependent on the metabolic balance of a number of electrolytes and hormones. The calcium ion plays a major role in muscle contraction and is rigorously controlled within narrow limits. Open-heart surgery imposes metabolic disturbances on both electrolytes and hormones, especially ionized calcium. Normally, ionized calcium levels are controlled by parathyroid hormone with a negative feedback from the ionized calcium controlling the system, but the results from this study suggest that during open-heart procedures, ionized calcium does not impose its normal negative feedback on bioactive parathyroid hormone secretion. The low blood pH levels that occurred during the operative conditions of the patients studied and the level of hypothermia imposed on the circulating blood during cardiopulmonary bypass appeared to influence the control of parathyroid hormone secretion, causing high levels of hormone to be secreted during this period.

This article has been cited by other articles:

				Y. Nakamura, H. Kuroda, N. Takemoto, S. Ohgi, and T. Mori Risk of low calcium and high magnesium in continuous warm hyperkalemic cardioplegia Ann. Thorac. Surg., October 1, 1999; 68(4): 1295 - 1301. [Abstract] [Full Text] [PDF]

				G. A Berg, D. Wheatley, W. W Borland, and F. J Dryburgh Changes in calcium fractions during cardiopulmonary bypass in infants and neonates Perfusion, May 1, 1993; 8(3): 209 - 219. [Abstract] [PDF]