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Ann Thorac Surg 1983;35:637-642
© 1983 The Society of Thoracic Surgeons

Articles

Hemodynamic Effects of Intraaortic Administration of Protamine

Alfredo L. Pauca, M.D.*, Joseph E. Graham, M.D., Allen S. Hudspeth, M.D.

From the Departments of Anesthesia and Surgery, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC

Accepted for publication July 23, 1982.

* Address reprint requests to Dr. Pauca, Department of Anesthesia, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103

Seventy-nine consecutive patients were given protamine rapidly into the ascending aorta during neutralization of heparin at the end of cardiopulmonary bypass. Simultaneously left atrial, diastolic pulmonary arterial, or right atrial pressures were maintained constant by appropriate infusion of oxygenated blood into the aorta. The systemic and pulmonary vascular resistances did not change, mean arterial blood pressure increased slightly, and cardiac output increased significantly (p < 0.001). It seems that this method of heparin neutralization is safe provided that the intravascular volume can be maintained constant.




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