HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Balderman, S. C. Articles by Gage, A. A. Search for Related Content PubMed PubMed Citation Articles by Balderman, S. C. Articles by Gage, A. A.

The Annals of Thoracic Surgery, Vol 35, 605-614, Copyright © 1983 by The Society of Thoracic Surgeons

ARTICLES

The optimal temperature for preservation of the myocardium during global ischemia

SC Balderman, JP Binette, AW Chan and AA Gage

To determine the myocardial temperature that provides maximal preservation of the heart during global ischemic arrest, five groups of dogs were studied (6 per group). In all animals, the aorta was cross- clamped for 120 minutes. Serial biopsies were done for determination of adenosine triphosphate and creatine phosphate, and study by electron microscopy. Starling curves were derived prior to cardiopulmonary bypass and 60 minutes after bypass. Mitochondrial changes were graded on a scale of 0 to 4. In the control group (Group 1), the aorta was clamped when the rectal temperature reached 25 degrees C (myocardial temperature, 18 degrees to 22 degrees C). In Groups 2, 3, 4, and 5, myocardial temperature was maintained at 6 degrees C, 10 degrees C, 14 degrees C, and 18 degrees C (all +/- 2 degrees C), respectively, by the use of systemic and topical hypothermia and repeated injections of cold cardioplegic solution into the aortic root. All groups showed a depression of left ventricular stroke work index, particularly Group 1 (no survivors), Group 2, and Group 3. The high-energy phosphate stores were well preserved in all groups except Group 1. The mitochondrial ultrastructure showed significant changes in all groups, especially Groups 1 and 5. These data indicate that satisfactory preservation of mitochondrial ultrastructure and high-energy phosphates was achieved at myocardial temperatures lower than 18 degrees C. Extreme hypothermia (Groups 2 and 3) was associated with significant reduction in ventricular function under the experimental conditions employed.

This article has been cited by other articles:

				J. A. Dearani, T. C. Axford, M. A. Patel, N. A. Healey, P. T. Lavin, and S. F. Khuri Role of myocardial temperature measurement in monitoring the adequacy of myocardial protection during cardiac surgery Ann. Thorac. Surg., December 1, 2001; 72(6): S2235 - 2243. [Abstract] [Full Text] [PDF]

				D. S Hundley, R. A Vertrees, L. Brownstein, M. Clancy, A. P Garwood, and A. J DeiRossi Determination and comparison of heat exchange efficiency of four commercially available blood cardioplegia sets Perfusion, January 1, 1994; 9(5): 343 - 347. [Abstract] [PDF]