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Ann Thorac Surg 1983;35:367-371
© 1983 The Society of Thoracic Surgeons

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Articles

Should Ventricular Fibrillation Be Induced Prior to the Infusion of Cardioplegic Solution?

From the Departments of Surgery and Medicine (Cardiology), Queen's University, Kingston, Ont, Canada

Accepted for publication March 2, 1982.

^* Address reprint requests to Dr. Salerno, Department of Surgery, Royal Victoria Hospital, Suite S-624, 687 Pine Ave W, Montreal, PQ, Canada H3A 1A1

The present study evaluates the metabolic effects on the left ventricular energy stores of a clinically used cardioplegic solution that was infused into the ascending aorta of pigs while the heart was either fibrillating (induced ventricular fibrillation) or in normal sinus rhythm prior to aortic clamping. Fibrillating hearts had lower stores of glycogen in the epicardium and endocardium compared with hearts in normal sinus rhythm. There was no difference in the stores of creatine phosphate between the hearts for both the epicardium and endocardium, but stores of adenosine triphosphate (ATP) in both layers were lower in fibrillating hearts. These results indicate that for ideal myocardial protection the cardioplegic solution should be infused while the heart is beating under cardiopulmonary bypass, and that ventricular fibrillation induced and maintained prior to cross-clamping may cause myocardial damage.

This article has been cited by other articles:

				T. A. Salerno and M. A. Chiong Ventricular Fibrillation Induced Prior to Cardioplegic Arrest in Hypertrophied Pig Hearts Ann. Thorac. Surg., August 1, 1983; 36(2): 152 - 160. [Abstract] [PDF]

				J. P. W. Heaton and T. A. Salerno Single Aortic Clamping for Proximal and Distal Anastomoses in Coronary Operations: Study of Myocardial Temperatures in Nonvented Hearts Ann. Thorac. Surg., May 1, 1983; 35(5): S0003497510604274 - S0003497510604274. [Abstract] [PDF]