HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Peter Van Trigt Thomas L. Spray Michael K. Pasque Robert B. Peyton Charles M. Christian Andrew S. Wechsler Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Van Trigt, P. Articles by Wechsler, A. S. Search for Related Content PubMed PubMed Citation Articles by Van Trigt, P. Articles by Wechsler, A. S.

Ann Thorac Surg 1983;35:3-13
© 1983 The Society of Thoracic Surgeons

---

Articles

The Influence of Time on the Response to Dopamine after Coronary Artery Bypass Grafting: Assessment of Left Ventricular Performance and Contractility Using Pressure/Dimension Analyses

From the Departments of Surgery and Anesthesiology, Duke University Medical Center, Durham, NC

^* Address reprint requests to Dr. Van Trigt, Box 3235, Duke University Medical Center, Durham, NC 27710

Pressure and dimension analyses were used to quantitate the changing cardiac response to dopamine over a 24-hour interval after coronary artery bypass grafting (CABG). Ultrasonic dimension transducers were utilized to measure the minor-axis diameter of the left ventricle, and matched micro-manometers were inserted to measure intracavitary left ventricular pressure and intrathoracic pressure. Pressure and dimension data were recorded and analyzed by computer during dopamine infusion at 0, 2.5, 5.0, and 10.0 µg per kilogram per minute, at periods designated as early (2 to 4 hours after CABG) and late (18 to 24 hours after CABG). Myocardial contractile responses to dopamine (peak velocity of minor-axis shortening, maximal excursion) were similar at each dose in the early and late studies. However, overall hydraulic performance, as reflected by cardiac outputs and the areas of the pressure/diameter work loops, had augmented late dose responses. This study suggests a major change in the relationship between the heart and peripheral control mechanisms that may partially explain diminishing inotropic requirements over time, in addition to the generally accepted occurrence of improvement in contractile state and functional reserve following cardiac operation.

This article has been cited by other articles:

				H.-J. Fahn, L.-S. Wang, B.-S. Huang, M.-H. Huang, and K.-Y. Chien Tumor recurrence in long-term survivors after treatment of carcinoma of the esophagus Ann. Thorac. Surg., March 1, 1994; 57(3): 677 - 681. [Abstract] [PDF]