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The Annals of Thoracic Surgery, Vol 34, 96-106, Copyright © 1982 by The Society of Thoracic Surgeons
LH Edmunds Jr
Thromboembolic complications associated with twelve different models of
currently available aortic and mitral valve prostheses are reviewed. There
is a need to standardize definitions of thrombotic phenomena and to report
these events for valve model and anatomic location actuarially and in terms
of incidence per 100 patient-years of follow- up. The incidence of
thromboemboli is less than 2 per 100 patient-years for aortic biological
valves without coumarin anticoagulation and for the best mechanical valves
with coumarin. For mitral biological prostheses with and without coumarin,
and for the best mechanical mitral valves with coumarin, the incidence
approximates 4 per 100 patient years. The incidence of mortality and
morbidity due to coumarin anticoagulation in patients with prosthetic
valves is 0.17 and 2.2 per 100 patient-years, respectively. Omission, poor
control or withdrawal of coumarin anticoagulation substantially increases
the incidence of thromboemboli in patients with mechanical valves. Some
reports suggest that the combination of dipyridamole and coumarin may
further reduce thromboembolic complications without increasing bleeding
problems. Atrial fibrillation clearly increases thromboembolic
complications, but the importance of other factors such as atrial clot,
large left atrial size, history of emboli, and first postoperative year is
less definite.
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