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The Annals of Thoracic Surgery, Vol 34, 74-80, Copyright © 1982 by The Society of Thoracic Surgeons
KW Marck and CR Wildevuur
For immunogenetic and economical reasons, an operative technique for lung
transplantation in the rat was developed. With the use of an operation
microscope and 8-0, 9-0, and 10-0 sutures, the left pulmonary artery, vein,
and brochus were anastomosed. The mean operation time was 4 hours; the mean
graft ischemia time, 87 minutes. After frequent failures initially, due to
anesthetic problems and lack of experience with microsurgical operative
technique, a final peroperative survival of about 80% was obtained.
Postoperative mortality approximated 50%. The main cause of postoperative
death was thrombus formation at the site of an anastomosis. In a final
series of 28 isogeneic transplantations, proper data for a one-month
follow-up was obtained from 36% of the animals that underwent operation, a
percentage comparable with initial canine pulmonary and rat renal
transplantation studies. Left lung transplantation in the rat proved to be
technically feasible and may provide an immunogenetically well defined and
economically advantageous animal model in lung transplantation research.
ARTICLES
Lung transplantation in the rat: I. Technique and survival
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