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Ann Thorac Surg 1982;34:66-70
© 1982 The Society of Thoracic Surgeons

Articles

Clinical Staging and the Tendency of Malignant Pleural Mesotheliomas to Remain Localized

Russell J. Nauta, M.D., Robert T. Osteen, M.D.*, Karen H. Antman, M.D., J. Kenneth Koster, M.D.

From the Department of Surgery, Brigham and Women's Hospital, and the Department of Medicine, Sidney Farber Cancer Institute, Harvard Medical School, Boston, MA

Accepted for publication November 30, 1981.

* Address reprint requests to: Dr. Osteen, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115

Thirty-two patients who had been treated for diffuse, malignant pleural mesotheliomas were retrospectively staged according to the system of Butchart. Nineteen of the 26 patients who were seen with disease confined to one hemithorax have died. Twelve patients died without progression to a higher clinical stage, and only 1 patient died of systemic metastases. Nineteen of the 32 patients died of local tumor invasion. Regimens containing Adriamycin (doxorubicin hydrochloride) appeared to prolong the survival of patients with epithelial-type tumors. Combination chemotherapy, designed to treat soft-tissue sarcomas, produced only partial responses in a small number of patients.




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