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Ann Thorac Surg 1982;33:599-604
© 1982 The Society of Thoracic Surgeons

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Articles

Carcinoma of the Lung: Evaluation of Histological Grade and Factors Influencing Prognosis

From the Division of Radiation Oncology and the Departments of Radiology, Pathology, and Surgery, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA

Accepted for publication November 20, 1981.

^* Address reprint requests to Dr. Chung, Division of Radiation Oncology, Department of Radiology, The Milton S. Hershey Medical Center, Hershey, PA 17033

The results in 96 patients with lung cancer who underwent lobectomy or pneumonectomy were analyzed. In reviewing the case histories of these patients, it became apparent that those with poorly differentiated tumor (grade 3) have an increased likelihood of positive lymph node metastases compared with those with well-differentiated (grade 1) or moderately differentiated (grade 2) tumor. Poor differentiation of the tumor, vascular invasion, and lymph node metastases appear to represent poor prognostic indices in patients undergoing operation.

Compared with patients with grade 1 and grade 2 tumors, patients with a grade 3 adenocarcinoma had more local recurrences, while those with grade 3 squamous cell carcinoma had more distant metastases. The findings suggest that histological grading is an important adjunct to the clinical evaluation of and planning of treatment for patients with lung cancer.

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