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Ann Thorac Surg 1982;33:480-485
© 1982 The Society of Thoracic Surgeons

Articles

The Physical Properties of Bovine Pericardium: A Study of the Effects of Stretching during Chemical Treatment in Glutaraldehyde

I.J. Reece, M.B., F.R.C.S.*, R. van Noort, B.Sc., D.Phil., T.R.P. Martin, B.Sc., M.Sc., D.Phil., M.M. Black, M.Sc., Ph.D.

From the Departments of Cardiothoracic Surgery and Medical Physics and Clinical Engineering, Royal Hallamshire Hospital, and the Department of Restorative Dentistry, Charles Clifford Dental Hospital, Sheffield, England

Accepted for publication July 16, 1981.

* Address reprint requests to Mr. Reece, Department of Cardiothoracic Surgery, Royal Hallamshire Hospital, Glossop RD, Sheffield S10 2JF, England

The uniaxial stress/strain response of bovine pericardium up to a stress of 1 N/mm2 was studied. The tissue was chemically modified in 0.5% buffered glutaraldehyde for 24 hours under various conditions of constraint. Four groups were studied: an unrestricted control group, a group held at their original length, a group stretched to a stress of 0.04 N/mm2, and a group stretched to a stress of 0.4 N/mm2 during treatment. Histological examination revealed changes in structural organization of the collagen, which explained the alterations in the stress/strain response. A significant alteration in mechanical properties after glutaraldehyde treatment was observed, with considerable loss of extensibility for the prestretched tissues. A valve made from such a prestretched tissue may be stenotic and possibly subject to early failure.






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Copyright © 1982 by The Society of Thoracic Surgeons.