ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Robert N. Jones
Robert B. Peyton
Thomas L. Spray
Peter Van Trigt
Andrew S. Wechsler
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jones, R. N.
Right arrow Articles by Wechsler, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jones, R. N.
Right arrow Articles by Wechsler, A. S.

Ann Thorac Surg 1981;32:546-553
© 1981 The Society of Thoracic Surgeons

Articles

Transmural Gradient in High-Energy Phosphate Content in Patients with Coronary Artery Disease

Robert N. Jones, M.D.*, Robert B. Peyton, M.D., Richard L. Sabina, Ph.D., Judith L. Swain, M.D., Edward W. Holmes, M.D., Thomas L. Spray, M.D., Peter Van Trigt, M.D., Andrew S. Wechsler, M.D.

From the Departments of Surgery and Medicine, Duke University Medical Center, Durham, NC

* Address reprint requests to Dr. Jones, Duke University Medical Center, Box 3040, Durham, NC 27710

In 16 patients undergoing elective coronary artery bypass, transmural biopsies were performed during bypass but before global ischemia. Subendocardial and subepicardial halves were separately assayed in each sampled tissue. Adenosine triphosphate (ATP) levels, total adenine nucleotide content ({Sigma}Ad), and creatine phosphate (CP) content were significantly higher (p < 0.005) in the subepicardium than the subendocardium in regions of the heart distal to major occlusions: 35.36 ± 2.12 nmole/mg versus 28.7 ± 1.7 (ATP), 42.24 ± 2.04 versus 35.6 ± 1.6 ({Sigma}Ad), and 29.99 ± 4.32 versus 16.35 ± 3.48 (CP). The opposite was true in two hearts with normal coronary arteries, in which high-energy phosphates tended to be higher in the subendocardium than the subepicardium. A transmural metabolic gradient therefore exists in regions of the myocardium distal to significant coronary occlusive disease. The subendocardium's relative depression in metabolic reserve could determine its susceptibility to ischemic damage and influence techniques designed to preserve the heart during ischemia.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
J. T. Cope, M. C. Mauney, D. Banks, O. A. R. Binns, N. F. De Lima, S. A. Buchanan, K. S. Shockey, S. W. Wilson, I. L. Kron, and C. G. Tribble
Controlled Reperfusion of Cardiac Grafts From Non--Heart-Beating Donors
Ann. Thorac. Surg., November 1, 1996; 62(5): 1418 - 1423.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
B. S. Allen, D. Murcia-Evans, and R. S. Hartz
Integrated Cardioplegia Allows Complex Valve Repairs in All Patients
Ann. Thorac. Surg., July 1, 1996; 62(1): 23 - 29.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
M. C. Mauney, J. T. Cope, O. A. R. Binns, R. C. King, K. S. Shockey, S. A. Buchanan, S. W. Wilson, J. Cogbill, I. L. Kron, and C. G. Tribble
Non-Heart-Beating Donors: A Model of Thoracic Allograft Injury
Ann. Thorac. Surg., July 1, 1996; 62(1): 54 - 61.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
H. M. Hanafy, B. S. Allen, J. W. Winkelmann, J. Ham, D. Osimani, and R. S. Hartz
Warm blood cardioplegic induction: An underused modality
Ann. Thorac. Surg., December 1, 1994; 58(6): 1589 - 1594.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. W. Hammon Jr., T. P. Graham Jr., R. J. Boucek Jr., M. D. Parrish, W. H. Merrill, and H. W. Bender Jr.
Myocardial Adenosine Triphosphate Content as a Measure of Metabolic and Functional Myocardial Protection in Children Undergoing Cardiac Operation
Ann. Thorac. Surg., November 1, 1987; 44(5): 467 - 470.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. J. Takach, L. R. Glassman, A. L. Milewicz, and R. E. Clark
Continuous Measurement of Intramyocardial pH: Relative Importance of Hypothermia and Cardioplegic Perfusion Pressure and Temperature
Ann. Thorac. Surg., October 1, 1986; 42(4): 365 - 371.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. J. Takach, L. R. Glassman, G. H. Ribakove, and R. E. Clark
Continuous Measurement of Intramyocardial pH: Correlation to Functional Recovery Following Normothermic and Hypothermic Global Ischemia
Ann. Thorac. Surg., July 1, 1986; 42(1): 31 - 36.
[Abstract] [PDF]

Home page
 Ann. Thorac. Surg.Home page
N. A. Silverman, S. Levitsky, J. Kohler, M. Trenkner, and H. Feinberg
Prevention of Reperfusion Injury Following Cardioplegic Arrest by Pulsatile Flow
Ann. Thorac. Surg., May 1, 1983; 35(5): S0003497510604225 - S0003497510604225.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1981 by The Society of Thoracic Surgeons.