HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Richard M. Engelman John H. Rousou Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Engelman, R. M. Articles by Dobbs, W. A. Search for Related Content PubMed PubMed Citation Articles by Engelman, R. M. Articles by Dobbs, W. A.

Ann Thorac Surg 1981;32:528-535
© 1981 The Society of Thoracic Surgeons

---

Articles

Fluosol-Da: An Artificial Blood for Total Cardiopulmonary Bypass

From the Departments of Surgery, University of Connecticut Health Center, Farmington, CT, and the Baystate Medical Center, Springfield, MA

^* Address reprint requests to Dr. Engelman, Chief of Cardiac Surgery, Baystate Medical Center, 759 Chestnut St, Springfield, MA 01107

The isolated, in situ pig heart model was used to determine if Fluosol could support myocardial function during cardiopulmonary bypass. Fourteen pigs were utilized; 7 underwent studies of myocardial metabolism (coronary blood flow and vascular resistance, myocardial oxygen consumption and extraction, lactate extraction, and adenosine triphosphate and creatine phosphate levels), and 7 underwent studies of myocardial contractility and compliance (intraventricular balloon measurements). Each study was carried out utilizing one hour of control hemic perfusion, followed by one hour of Fluosol perfusion, and followed by a third hour of a return of hemic perfusion.

The results documented that in the vented, beating, nonischemic heart, myocardial metabolism and functional measurements are maintained during an hour of Fluosol perfusion. However, because of an increased level of ionized calcium during Fluosol perfusion, myocardial functional measurements document significantly increased contractility. The increased contractility is associated with an increase in anaerobic metabolism. The latter contributes to a decline in the high-energy phosphate level following a return of hemic perfusion as the heart recovers from the increased work load placed on it during Fluosol perfusion.

It is concluded that there is sufficient oxygen-carrying capacity in Fluosol-DA to maintain cardiac function during perfusion in the large animal model. However, the carrier solution for the Fluosol must be adjusted to appropriate electrolyte content to avoid adverse effects on the myocardium.

This article has been cited by other articles:

				M. Yamazaki, R. Aeba, R. Yozu, and K. Kobayashi Use of Hemoglobin Vesicles During Cardiopulmonary Bypass Priming Prevents Neurocognitive Decline in Rats Circulation, July 4, 2006; 114(1_suppl): I-220 - I-225. [Abstract] [Full Text] [PDF]

				A. Marchbank Fluorocarbon emulsions Perfusion, March 1, 1995; 10(2): 67 - 88. [PDF]

				S. M. Martin, H. Laks, D. C. Drinkwater, D. G. Stein, E. R. Capouya, J. M. Pearl, S. W. Barthel, P. Chang, E. Kaczer, and S. Bhuta Perfluorochemical reperfusion yields improved myocardial recovery after global ischemia Ann. Thorac. Surg., April 1, 1993; 55(4): 954 - 960. [Abstract] [PDF]

				B. Teicher and C. Rose Perfluorochemical emulsions can increase tumor radiosensitivity Science, March 2, 1984; 223(4639): 934 - 936. [Abstract] [PDF]