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Ann Thorac Surg 1981;32:486-494
© 1981 The Society of Thoracic Surgeons

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Articles

The Harmful Effects of Ventricular Distention during Postischemic Reperfusion

From the Departments of Surgery and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD

^* Address correspondence to Dr. Gardner, Blalock 665, The Johns Hopkins Hospital, Baltimore, MD 21205

To assess the effects of left ventricular distention during the early reperfusion period following ischemic arrest, 16 canine heart preparations were subjected to 45 minutes of hypothermic (27°C) cardioplegic arrest and normothermic reperfusion. Isovolumic left ventricular developed pressure and rate of rise of left ventricular pressure (dP/dt) were measured with an intraventricular balloon; endocardial/epicardial flow ratios were determined with microspheres; and myocardial gas tensions were monitored with mass spectrometry.

During early reperfusion, Group 1 hearts (n = 8) were not distended (end-diastolic pressure = 0). Group 2 hearts (n = 8) were subjected to an end-diastolic pressure of 20 mm Hg for the initial 15 minutes of reperfusion. Group 2 hearts demonstrated impaired subendocardial blood flow after 5 minutes of reflow (0.75 ± 0.06 vs 0.96 ± 0.04, endocardial/epicardial flow rates, Group 2 vs Group 1) and persistent elevation of intramyocardial carbon dioxide (CO₂) tension (68 ± 4 vs 51 ± 4 mm Hg, Group 2 vs Group 1). In addition, postischemic ventricular function was significantly worse in Group 2 hearts (60 ± 7 vs 79 ± 3% of control dP/dt, Group 2 vs Group 1, and 53 ± 6 vs 81 ± 5% of control left ventricular developed pressure, Group 2 vs Group 1).

These data demonstrate that even mild distention during early reperfusion can result in reduced subendocardial perfusion and delayed washout of tissue CO₂. Although myocardial blood flow and CO₂ tension subsequently returned to normal in the distended hearts, left ventricular performance remained significantly depressed. This injury can occur clinically in nonvented hearts prior to the resumption of effective ventricular contraction.

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