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Ann Thorac Surg 1981;32:146-153
© 1981 The Society of Thoracic Surgeons
Surgery Branch, Laboratory of Pathology, and Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD
* Address reprint requests to Dr. Burt, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 10N116, Bethesda, MD 20205
Twenty consecutive patients with pulmonary infiltrates undiagnosed by routine, noninvasive methods were entered into a prospective study designed to evaluate the diagnostic yield of four methods of lung biopsy. Percutaneous aspiration needle, cutting needle, transbronchial, and open (anterior thoracotomy) biopsy were performed synchronously on all patients. Specimens were evaluated by microbiological, virological, and pathological methods. The diagnostic yields of the four methods were as follows: aspiration needle, 29%; cutting needle, 53%; transbronchial, 59%; and open lung biopsy, 94%. Open lung biopsy was significantly better in yielding a diagnosis than aspiration needle (p < 0.001), cutting needle (p < 0.001), and transbronchial biopsy (p < 0.04).
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