HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Jack A. Roth Ramon A. Cukingnan John Brazier Donald L. Morton Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Roth, J. A. Articles by Morton, D. L. Search for Related Content PubMed PubMed Citation Articles by Roth, J. A. Articles by Morton, D. L.

Ann Thorac Surg 1981;31:350-356
© 1981 The Society of Thoracic Surgeons

---

Articles

Cell-Mediated Immunity Is Depressed Following Cardiopulmonary Bypass

Divisions of Thoracic Surgery and Oncology, UCLA School of Medicine, Los Angeles, and Surgical Services, Sepulveda Veterans Administration Hospital, Sepulveda, CA

Accepted for publication July 7, 1980.

^* Address reprint requests to Dr. Roth, Bldg 10, Rm 10N202, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205

Sequential in vitro lymphocyte function tests in 13 patients undergoing cardiac operation were performed to determine factors that contribute to depressed cell-mediated immunity following operation. Lymphocytes were stimulated with phytohemagglutinin (PHA), pokeweed mitogen, concanavalin A (Con A), and mitomycin-treated, pooled, allogeneic lymphocytes (MLC). Mitogen responses were measured by³ H-labeled thymidine incorporation. Circulating levels of T, B, and Fc-receptor lymphocytes were determined by counting E, EAC, and EA rosettes. Serum cortisol was measured by radioimmunoassay.

The T-cell-dependent lymphocyte responses (PHA, Con A, and MLC) were significantly decreased 24 hours after operation, and this was accompanied by a 60% decrease in circulating T-cell levels. The PHA, Con A, and MLC responses, and circulating T-cell levels returned to preoperative values one week following operation.

Lymphocyte responses to mitogens remained significantly decreased when the number of T cells in the postoperative cultures were adjusted to preoperative levels. This indicates that the T cells remaining after operation were functionally impaired. We conclude that lymphocyte proliferative responses and antigen recognition are significantly depressed following cardiac operation, and that these responses are related to decreased numbers of circulating T lymphocytes and depressed function of the remaining T lymphocytes.

This article has been cited by other articles:

				H. Bayram, D. Erer, E. Iriz, M. Zor, O. Gulbahar, and M. Ozdogan Comparison of the effects of pulsatile cardiopulmonary bypass, non-pulsatile cardiopulmonary bypass and off-pump coronary artery bypass grafting on the inflammatory response and S-100beta protein Perfusion, January 1, 2012; 27(1): 56 - 64. [Abstract] [PDF]

				C. A. Efthymiou and W. I. Weir Salmonella sepsis simulating gastrointestinal ischaemia following cardiopulmonary bypass Interact CardioVasc Thorac Surg, February 1, 2011; 12(2): 334 - 336. [Abstract] [Full Text] [PDF]

				J. W. Hammon Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation Card. Surg. Adult, January 1, 2008; 3(2008): 370 - 389. [Full Text]

				T. Sano, S. Morita, M. Masuda, Y. Tomita, T. Nishida, H. Tatewaki, and H. Yasui Cardiopulmonary bypass, steroid administration, and surgical injury synergistically impair memory T cell function and antigen presentation Interact CardioVasc Thorac Surg, December 1, 2003; 2(4): 598 - 602. [Abstract] [Full Text] [PDF]

				P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]

				H. Mayumi, Q.-W. Zhang, A. Nakashima, M. Masuda, H. Kohno, Y. Kawachi, and H. Yasui Synergistic Immunosuppression Caused by High-Dose Methylprednisolone and Cardiopulmonary Bypass Ann. Thorac. Surg., January 1, 1997; 63(1): 129 - 137. [Abstract] [Full Text]

				P. Hornick Cardiopulmonary bypass and the adaptive immune system: perspectives on T cell function Perfusion, May 1, 1996; 11(3): 281 - 290. [PDF]

				A. Aris, J. Pomar, and E. Saura Cardiopulmonary bypass in HIV-positive patients Ann. Thorac. Surg., May 1, 1993; 55(5): 1104 - 1108. [Abstract] [PDF]

				K. Tajima, F. Yamamoto, K. Kawazoe, I. Nakatani, H. Sakai, T. Abe, and Y. Kawashima Cardiopulmonary bypass and cellular immunity: Changes in lymphocyte subsets and natural killer cell activity Ann. Thorac. Surg., March 1, 1993; 55(3): 625 - 630. [Abstract] [PDF]

				D. M. Nguyen, D. S. Mulder, and H. Shennib Effect of cardiopulmonary bypass on circulating lymphocyte function Ann. Thorac. Surg., April 1, 1992; 53(4): 611 - 616. [Abstract] [PDF]

				H. Ide, T. Kakiuchi, N. Furuta, H. Matsumoto, K.-i. Sudo, A. Furuse, and K.-i. Asano The Effect of Cardiopulmonary Bypass on T Cells and Their Subpopulations Ann. Thorac. Surg., September 1, 1987; 44(3): 277 - 282. [Abstract] [PDF]

				D. V. Feliciano, R. B. O'Gorman, C. G. Bitondo, P. A. Cruse, R. H. Matthews, and K. S. Matthews Lymphocyte Function and Abdominal Operations: Trauma vs Elective Surgery Arch Surg, June 1, 1987; 122(6): 697 - 701. [Abstract] [PDF]

				B. S. Linn and J. Jensen Age and Immune Response to a Surgical Stress Arch Surg, April 1, 1983; 118(4): 405 - 409. [Abstract] [PDF]

				R. H. Breyer, R. I. Andrews, S. A. Mills, A. R. Cordell, and E. T. Ahl Probable Herpes Simplex Pneumonia After Aortic Valve Replacement JAMA, March 11, 1983; 249(10): 1319 - 1322. [Abstract] [PDF]