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The Annals of Thoracic Surgery, Vol 30, 259-266, Copyright © 1980 by The Society of Thoracic Surgeons

ARTICLES

Spontaneous degeneration of porcine bioprosthetic valves

DJ Magilligan Jr, JW Lewis Jr, FM Jara, MW Lee, M Alam, JM Riddle and PD Stein

From October, 1971, to October, 1979, 490 patients with 560 porcine bioprosthetic valves were discharged from the hospital. During these 8 years, 23 valves were removed because of failure due to spontaneous degeneration. Bioprosthetic valve survival without degeneration was at 4 years, 98.9% +/- 86 (standard error); at 5 years, 96.4% +/- 1.3; at 6 years, 90.8% +/- 2.4; and at 7 years, 84.2% +/- 3.7. There was no difference in degeneration observed with regard to sex, valve position, or whether the valves were rinsed with antibiotics prior to implantation. There was an increase in degeneration in patients 35 years old and younger compared with those more than 35 years old (p = 0.0001). Valve failure was gradual, and valve changes were noted by echocardiogram and phonocardiogram prior to actual failure. Specific factors leading to degeneration require further investigation.

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