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Ann Thorac Surg 1980;30:259-266
© 1980 The Society of Thoracic Surgeons
From the Department of Surgery, Division of Cardiac and Thoracic Surgery, the Department of Medicine, Divisions of Cardiovascular Medicine and Rheumatology, and the Department of Pathology, Henry Ford Hospital, Detroit, MI
* Address reprint requests to Dr. Magilligan, Division of Cardiac and Thoracic Surgery, Henry Ford Hospital, Detroit, MI 48202
From October, 1971, to October, 1979, 490 patients with 560 porcine bioprosthetic valves were discharged from the hospital. During these 8 years, 23 valves were removed because of failure due to spontaneous degeneration. Bioprosthetic valve survival without degeneration was at 4 years, 98.9% ± 0.6 (standard error); at 5 years, 96.4% ± 1.3; at 6 years, 90.8% ± 2.4; and at 7 years, 84.2% ± 3.7. There was no difference in degeneration observed with regard to sex, valve position, or whether the valves were rinsed with antibiotics prior to implantation. There was an increase in degeneration in patients 35 years old and younger compared with those more than 35 years old (p = 0.0001). Valve failure was gradual, and valve changes were noted by echocardiogram and phonocardiogram prior to actual failure. Specific factors leading to degeneration require further investigation.
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