The Annals of Thoracic Surgery, Vol 29, 444-450, Copyright © 1980 by The Society of Thoracic Surgeons
Application of multivariate analysis to the enzyme patterns in the serum of patients undergoing coronary artery operation
LD Voegele, AJ Gross, WH Prioleau Jr and P Hairston
Serial determinations of serum glutamic oxaloacetic transaminase, lactic
dehydrogenase, and creatine phosphokinase were performed in 50 consecutive
patients undergoing cardiac operation for coronary artery bypass or
combined valve replacement and coronary artery bypass. Thirty- seven
patients (74%) who demonstrated minimal or no changes on the
electrocardiogram manifested a recognizable pattern of distribution of the
enzyme sequences. The pattern of these patients served as controls for the
detection of abnormal patterns. All other patients were grouped together,
regardless of clinical behavior. Perioperative myocardial infarction was
established in 5 patients (10%) and resulted in 1 death. The purpose of
this study was to apply discriminant analysis to two clinically determined
patient groups in order to ascertain whether the three enzyme readings can
be used to classify patients into their respective groups. The results
suggest that enzyme profiles reflect degrees of myocardial damage that can
serve to identify clinical infarction.
