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The Annals of Thoracic Surgery, Vol 29, 346-350, Copyright © 1980 by The Society of Thoracic Surgeons

ARTICLES

Protective effect of hyaluronidase after long-term aortic cross- clamping: initial experimental observations

D Vij, LH Toledo-Pereyra, DJ Magilligan Jr and FM Jara

This work studies the effect of hyaluronidase on myocardium subjected to long-term aortic cross-clamping (three hours) and moderate hypothermia (28 degrees C). Animals receiving hyaluronidase (1,00o U per liter) through the root of the aorta with a procaine-potassium chloride-lasmalyte cardioplegic solution showed better functional, electrical, and morphological response than the untreated animals. These findings, although preliminary, appear to be promising for potential clinical application.




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Copyright © 1980 by The Society of Thoracic Surgeons.