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Ann Thorac Surg 1980;29:346-350
© 1980 The Society of Thoracic Surgeons
Department of Surgery, Sections of Surgical Research and Thoracic Surgery, Henry Ford Hospital, Detroit, MI
Accepted for publication August 30, 1979.
* Address reprint requests to Dr. Toledo-Pereyra, Department of Surgery, Sections of Transplantation and Surgical Research, Mount Carmel Mercy Hospital and Medical Center, 6071 W Outer Drive, Detroit, MI 48235
This work studies the effect of hyaluronidase on myocardium subjected to long-term aortic cross-clamping (three hours) and moderate hypothermia (28°C). Animals receiving hyaluronidase (1,000 U per liter) through the root of the aorta with a procaine-potassium chloride-plasmalyte cardioplegic solution showed better functional, electrical, and morphological response than the untreated animals. These findings, although preliminary, appear to be promising for potential clinical application.
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