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Ann Thorac Surg 1980;29:209-216
© 1980 The Society of Thoracic Surgeons

Articles

Lung Transplantation: Better Survival Results after Graft Pretreatment with Concanavalin A or Chondroitin Sulfate

Luis H. Toledo-Pereyra, M.D., Ph.D.*, Hector Mejia-Michel, M.D., Manuel Chee, M.D.

From the Department of Surgery, Section of Transplantation and Surgical Research, Henry Ford Hospital, Detroit, MI, and the Department of Surgery, University of Minnesota, Minneapolis, MN

Accepted for publication June 29, 1979.

* Address reprint requests to Dr. Toledo-Pereyra, Department of Surgery, Section of Transplantation and Surgical Research, Mount Carmel Mercy Hospital, 6071 W Outer Drive, Detroit, MI 48235

Pretreatment of the lung graft with concanavalin A (Con A) or chondroitin sulfate (CIS) was used to modify the lung allograft response after transplantation into moderately immunosuppressed (low doses of azathioprine and prednisone) recipients. Significant (p < 0.05) prolongation of survival was observed after graft pretreatment. Pneumonia and rejection were the most frequent causes of death for all groups of dogs. However, only 3 out of 6 animals from each of the groups with pretreated grafts died of pneumonia or rejection, whereas 5 of the 6 animals in the control group died of these causes. Furthermore, when rejection occurred in the dogs with lung grafts pretreated with Con A or CIS, it was considerably delayed compared with the controls. Partial pressure of arterial oxygen, chest roentgenograms, and lung histology were good indicators of lung viability after transplantation.






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Copyright © 1980 by The Society of Thoracic Surgeons.