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Ann Thorac Surg 1980;29:74-75
© 1980 The Society of Thoracic Surgeons

Articles

Rifampin in the Management of Early Prosthetic Staphylococcus epidermidis Endocarditis

Ted George, M.D., Keith Burch, M.D., Donald J. Magilligan, Jr, M.D.*

Division of Cardiac and Thoracic Surgery, Henry Ford Hospital, Detroit, MI

Accepted for publication February 20, 1979.

* Address reprint requests to Dr. Magilligan, Division of Cardiac and Thoracic Surgery, 2799 W Grand Blvd, Detroit, MI 48202

Staphylococcus epidermidis endocarditis occurred four days following aortic valve replacement with a Björk-Shiley prosthesis. Antimicrobial therapy, shown to be effective by in vitro and in vivo studies, failed to eradicate the infection. When rifampin was added to the existing antibiotic regimen, peak serum bactericidal activity increased, the patient defervesced, and blood cultures became negative.




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