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The Annals of Thoracic Surgery, Vol 29, 74-75, Copyright © 1980 by The Society of Thoracic Surgeons

ARTICLES

Rifampin in the management of early prosthetic staphylococcus epidermidis endocarditis

T George, K Burch and DJ Magilligan Jr

Staphylococcus epidermidis endocarditis occurred four days following aortic valve replacement with a Bjork-Shiley prosthesis. Antimicrobial therapy, shown to be effective by in vitro and in vivo studies, failed to eradicate the infection. When rifampin was added to the existing antibiotic regimen, peak serum bactericidal activity increased, the patient defervesced, and blood cultures became negative.

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