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Philip A. Faraci
Harold F. Rheinlander
Richard J. Cleveland
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Ann Thorac Surg 1980;29:70-73
© 1980 The Society of Thoracic Surgeons

Articles

Use of Nitroprusside for Control of Pulmonary Hypertension in Repair of Ventricular Septal Defect

Philip A. Faraci, M.D.*, Harold F. Rheinlander, M.D., Richard J. Cleveland, M.D.

Department of Cardiothoracic Surgery, New England Medical Center Hospital, and Tufts University School of Medicine, Boston, MA

Accepted for publication January 9, 1979.

* Address reprint requests to Dr. Faraci, New England Medical Center Hospital, 171 Harrison Ave, Boston, MA 02111

After repair of a ventricular septal defect (VSD) in a 3-year-old child with markedly elevated pulmonary vascular resistance (PVR), sodium nitroprusside was administered by intravenous infusion at 3.0 µg per kilogram of body weight per minute. Nitroprusside was effective in reducing pulmonary artery pressure and increasing systemic blood pressure in the intraoperative and early postoperative periods. It is suggested that nitroprusside may facilitate the perioperative management and enhance the early survival in patients with increased PVR secondary to a VSD.






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