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Ann Thorac Surg 1980;29:49-56
© 1980 The Society of Thoracic Surgeons

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Articles

Cardiopulmonary Dynamics during Arteriovenous Perfusion: Cardiac Output, Pulmonary Arterial Resistance, and Right Ventricular Stroke Work

Departments of Surgery, Civil Engineering, and Neurological Surgery, University of Pittsburgh, Pittsburgh, PA

Accepted for publication February 5, 1979.

^* Address reprint requests to Dr. Griffith, University of Pittsburgh, School of Medicine, Department of Surgery, Pittsburgh, PA 15261

The effects of arteriovenous perfusion on myocardial performance, pulmonary circulatory dynamics, and organ preservation were studied in dogs in order to evaluate the applicability of arteriovenous extracorporeal membrane oxygenation for partial respiratory support. Studies were made on normally oxygenated dogs, on dogs made hypoxic by oxygen deprivation and ventilatory depression, and on dogs with pulmonary injury and moderate pulmonary hypertension induced by injection of oleic acid into the right ventricle. The latter two groups were included to assess the changes that occur in cardiopulmonary dynamics in the presence of hypoxia and pulmonary hypertension. A micro-channel membrane oxygenator was employed to provide partial respiratory support to the group of animals with pulmonary injury. The results indicate that no deleterious hemodynamic changes occurred in any of the groups of animals with arteriovenous flow for periods of up to 5 hours at rates corresponding to 20 to 35% of the total cardiac output. Adequate systemic oxygenation was provided by the microchannel oxygenator at these rates of arteriovenous perfusion.

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