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Ann Thorac Surg 1980;29:32-35
© 1980 The Society of Thoracic Surgeons

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Articles

Neomycin Absorption Following Clagett Procedure for Postpneumonectomy Empyema

Department of Surgery and Microbiology, Royal Victoria Hospital and McGill University, Montreal, Que, Canada

Accepted for publication February 1, 1979.

^* Address reprint requests to Dr. Meakins, Royal Victoria Hospital, Department of Surgery, Room S6.24, 687 Pine Ave West, Montreal, Que, Canada, H3A 1A1

Following a Clagett stage II procedure, significant amounts of neomycin are absorbed when concentrations of 0.25% neomycin (8.9 µg per milliliter) are used. If higher concentrations are employed, the neomycin can achieve toxic levels (40 µg per milliliter), with associated renal toxicity and respiratory suppression. The peel of the empyema cavity does not prevent absorption of drugs. Therefore, when drugs are inserted into an empyema cavity, due care must be exerted to prevent drug toxicity.

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