|
|
||||||||
Ann Thorac Surg 1979;28:509-521
© 1979 The Society of Thoracic Surgeons
From the Department of Surgery, Saint Louis University, St. Louis, MO.
* Address reprint requests to Dr. Barner, 1325 S Grand Blvd, St. Louis, MO 63104.
Cold blood with potassium, 34 mEq/L, was compared with cold blood and with a cardioplegic solution. Three groups of 6 dogs had 2 hours of aortic cross-clamp while on total bypass at 28°C with the left ventricle vented. An initial 5-minute coronary perfusion was followed by 2 minutes of perfusion every 15 minutes for the cardioplegic solution (8°C) and every 30 minutes for 3 minutes with cold blood or cold blood with potassium (8°C). Hearts receiving cold blood or cold blood with potassium had topical cardiac hypothermia with crushed ice. Peak systolic pressure, rate of rise of left ventricular pressure, maximum velocity of the contractile element, pressure volume curves, coronary flow, coronary flow distribution, and myocardial uptake of oxygen, lactate, and pyruvate were measured prior to ischemia and 30 minutes after restoration of coronary flow. Myocardial creatine phosphate (CP), adenosine triphosphate (ATP), and adenosine diphosphate (ADP) were determined at the end of ischemia and after recovery. Changes in coronary flow, coronary flow distribution, and myocardial uptake of oxygen and pyruvate were not significant. Peak systolic pressure and lactate uptake declined significantly for hearts perfused with cold blood but not those with cold blood with potassium. ATP and ADP were lowest in hearts perfused with cardioplegic solution, and CP and ATP did not return to control in any group. Heart water increased with the use of cold blood and cardioplegic solution. Myocardial protection with cold blood with potassium and topical hypothermia has some advantages over cold blood and cardioplegic solution.
This article has been cited by other articles:
![]() |
Y. Hayashi, Y. Sawa, M. Nishimura, H. Ichikawa, K. Kagisaki, S. Ohtake, and H. Matsuda Clinical evaluation of leukocyte-depleted blood cardioplegia for pediatric open heart operation Ann. Thorac. Surg., June 1, 2000; 69(6): 1914 - 1919. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Krejca, J. Skiba, P. Szmagala, T. Gburek, and B. Andrzej Cardiac troponin T release during coronary surgery using intermittent cross-clamp with fibrillation, on-pump and off-pump beating heart Eur J Cardiothorac Surg, September 1, 1999; 16(3): 337 - 341. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. S. Lawton, P.-W. Hsia, and R. J. Damiano Jr The adenosine-triphosphate-sensitive potassium-channel opener pinacidil is effective in blood cardioplegia Ann. Thorac. Surg., September 1, 1998; 66(3): 768 - 773. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Mezzetti, A. M. Calafiore, D. Lapenna, R. Deslauriers, G. Tian, T. A. Salerno, A. M. Verna, G. Bosco, S. D. Pierdomenico, and F. Caccurullo Intermittent antegrade warm cardioplegia reduces oxidative stress and improves metabolism of the ischemic-reperfused human myocardium J. Thorac. Cardiovasc. Surg., April 1, 1995; 109(4): 787 - 795. [Abstract] [Full Text] |
||||
![]() |
B. B. Roe Warm blood cardioplegia: Back to square one Ann. Thorac. Surg., February 1, 1993; 55(2): 330 - 331. [PDF] |
||||
![]() |
W. M. L. Neethling, J. J. van den Heever, S. Cooper, and J. M. Meyer Interstitial pH during myocardial preservation: Assessment of five methods of myocardial preservation Ann. Thorac. Surg., February 1, 1993; 55(2): 420 - 426. [Abstract] [PDF] |
||||
![]() |
H. B. Barner Blood cardioplegia: A review and comparison with crystalloid cardioplegia Ann. Thorac. Surg., December 1, 1991; 52(6): 1354 - 1367. [Abstract] [PDF] |
||||
![]() |
C. Munsch Review article : Blood cardioplegia Perfusion, October 1, 1991; 6(4): 245 - 252. [PDF] |
||||
![]() |
R. T. Card, K. Prasad, B. Bharadwaj, L. A. P. Hnatuk, and M. A. MacFadyen High 2,3-DPG Blood Cardioplegia and Myocardial Preservation During Cardiopulmonary Bypass Angiology, February 1, 1988; 39(2): 123 - 131. [Abstract] [PDF] |
||||
![]() |
K. Prasad, B. Bharadwaj, and R. T. Card Effects of Blood and Crystalloid Cardioplegia on Cardiac Function at Organ and Cellular Levels During Hypothermic Cardiac Arrest Angiology, January 1, 1988; 39(1): 23 - 33. [Abstract] [PDF] |
||||
![]() |
S. Levitsky Myocardial Protection Ann. Thorac. Surg., September 1, 1987; 44(3): 328 - 329. [PDF] |
||||
![]() |
J. Eugene, K. P. Lyons, R. A. Ott, V. L. Gelezunas, C. W. J. Chang, M. G. Kowall, and N. J. Haiduc Regional Myocardial Perfusion of Cardioplegic Solutions Ann. Thorac. Surg., May 1, 1987; 43(5): 522 - 526. [Abstract] [PDF] |
||||
![]() |
F. Oguma, S. Imai, and S. Eguchi Role Played by Oxygen in Myocardial Protection with Crystalloid Cardioplegic Solution Ann. Thorac. Surg., August 1, 1986; 42(2): 172 - 179. [Abstract] [PDF] |
||||
![]() |
J. E. Codd, H. B. Barner, D. G. Pennington, J. P. Merjavy, G. C. Kaiser, J. E. Devine, and V. L. Willman Intraoperative Myocardial Protection: A Comparison of Blood and Asanguineous Cardioplegia Ann. Thorac. Surg., February 1, 1985; 39(2): 125 - 133. [Abstract] [PDF] |
||||
![]() |
G. J. van der Vusse, W. A. Coumans, E. van der Veen, A. J. Drake, W. Flameng, and R. Suy ATP, Creatine Phosphate and Glycogen Content in Human Myocardial Biopsies: Markers for the Efficacy of Cardioprotection During Aorto-Coronary Bypass Surgery Vascular and Endovascular Surgery, May 1, 1984; 18(3): 127 - 134. [Abstract] [PDF] |
||||
![]() |
R. E. Clark, G. J. Magovern, I. Y. Christlieb, and S. Boe Nifedipine Cardioplegia Experience: Results of a 3-Year Cooperative Clinical Study Ann. Thorac. Surg., December 1, 1983; 36(6): 654 - 663. [Abstract] [PDF] |
||||
![]() |
G. L. Hicks, W. Arnold, and R. A. DeWall Fluorocarbon Cardioplegia and Myocardial Protection Ann. Thorac. Surg., May 1, 1983; 35(5): S0003497510604237 - S0003497510604237. [Abstract] [PDF] |
||||
![]() |
K. V. Arom, W. F. Northrup III, W. G. Lindsay, and D. M. Nicoloff Simplified System for Blood Cardioplegia Ann. Thorac. Surg., January 1, 1983; 35(1): 108 - 110. [Abstract] [PDF] |
||||
![]() |
F. P. Catinella, J. N. Cunningham Jr., P. X. Adams, S. L. Snively, R. I. Gross, and F. C. Spencer Myocardial Protection with Cold Blood Potassium Cardioplegia during Prolonged Aortic Cross-Clamping Ann. Thorac. Surg., March 1, 1982; 33(3): 228 - 233. [Abstract] [PDF] |
||||
![]() |
H. B. Barner, M. Jellinek, J. W. Standeven, L. J. Menz, and J. W. Hahn Cold Blood-Diltiazem Cardioplegia Ann. Thorac. Surg., January 1, 1982; 33(1): 55 - 63. [Abstract] [PDF] |
||||
![]() |
F. P. Catinella, J. N. Cunningham Jr, R. K. Srungaram, I. M. Nathan, E. A. Knopp, G. Paone, F. G. Baumann, P. X. Adams, and F. C. Spencer Blood Potassium Cardioplegia Administration: Comparison of Myocardial Protection Offered by Three Techniques Arch Surg, December 1, 1981; 116(12): 1509 - 1516. [Abstract] [PDF] |
||||
![]() |
R. E. Clark, I. Y. Christlieb, J. A. Spratt, P. D. Henry, A. E. Fischer, J. R. Williamson, and B. E. Sobel Myocardial Preservation with Nifedipine: A Comparative Study at Normothermia Ann. Thorac. Surg., January 1, 1981; 31(1): 3 - 20. [Abstract] [PDF] |
||||
![]() |
I. Y. Christlieb and R. E. Clark An Intracellular-like Cardioplegic Solution: Its Enhancement of Myocardial Protection Arch Surg, November 1, 1980; 115(11): 1339 - 1347. [Abstract] [PDF] |
||||
![]() |
H. B. Barner, G. C. Kaiser, J. E. Codd, D. H. Tyras, D. Glenn Pennington, H. Laks, and V. L. Willman Clinical Experience with Cold Blood as the Vehicle for Hypothermic Potassium Cardioplegia Ann. Thorac. Surg., March 1, 1980; 29(3): 224 - 227. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |