HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Jack A. Roth Ramon A. Cukingnan Calvin R. Scott Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Roth, J. A. Articles by Scott, C. R. Search for Related Content PubMed PubMed Citation Articles by Roth, J. A. Articles by Scott, C. R.

Ann Thorac Surg 1979;28:69-72
© 1979 The Society of Thoracic Surgeons

---

Articles

Use of Activated Coagulation Time to Monitor Heparin during Cardiac Surgery

From the Department of Thoracic Surgery, Wadsworth Veterans Administration Hospital and UCLA Medical Center, Los Angeles, CA

Accepted for publication November 1, 1978.

^* Address reprint requests to Dr. Cukingnan, 112G Wadsworth VA Hospital, Wilshire and Sawtelle Blvds, Los Angeles, CA 90073

Activated coagulation time (ACT) for protamine reversal was monitored in 28 consecutive patients (Group 1) and a standard heparin-protamine protocol was used for an earlier series of 28 patients (Group 2). Although Group 1 received a significantly higher total heparin dose than Group 2 (p < 0.01), the protamine dose for reversal was significantly less for the ACT group than for the controls (p < 0.0005). The mean ratio of protamine to total heparin was 1:1 (range, 0.33 to 1.44) for the ACT group and 2:1 (range, 1.42 to 2.59) for the controls. There were no significant differences between the two groups in operative and postoperative blood loss, transfusion requirements, hematocrit, and partial thromboplastin time. This study shows that the ACT test did not reduce postoperative bleeding significantly when compared with our standard protocol. It also indicates that there is wide individual sensitivity to heparin and that significantly less protamine is required for reversal.

This article has been cited by other articles:

				L. J. Enriquez and L. Shore-Lesserson Point-of-care coagulation testing and transfusion algorithms Br. J. Anaesth., December 1, 2009; 103(suppl_1): i14 - i22. [Abstract] [Full Text] [PDF]

				The Society of Thoracic Surgeons Blood Conservatio, V. A. Ferraris, S. P. Ferraris, S. P. Saha, E. A. Hessel II, C. K. Haan, B. D. Royston, C. R. Bridges, R. S.D. Higgins, G. Despotis, et al. Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline Ann. Thorac. Surg., May 1, 2007; 83(5_Supplement): S27 - S86. [Abstract] [Full Text] [PDF]

				G. J. Despotis, J. H. Joist, and L. T. Goodnough Monitoring of hemostasis in cardiac surgical patients: impact of point-of-care testing on blood loss and transfusion outcomes Clin. Chem., September 1, 1997; 43(9): 1684 - 1696. [Abstract] [Full Text] [PDF]

				C. Aren Review article : Heparin and protamine during cardiac surgery Perfusion, July 1, 1989; 4(3): 171 - 181. [PDF]

				T. L. Winton, E. J. P. Charrette, and T. A. Salerno The Cell Saver during Cardiac Surgery: Does It Save? Ann. Thorac. Surg., April 1, 1982; 33(4): 379 - 381. [Abstract] [PDF]

				W. S. Stoney, W. C. Alford Jr., G. R. Burrus, D. M. Glassford Jr., and C. S. Thomas Jr. Air Embolism and Other Accidents Using Pump Oxygenators Ann. Thorac. Surg., April 1, 1980; 29(4): 336 - 340. [Abstract] [PDF]