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Ann Thorac Surg 1979;28:28-32
© 1979 The Society of Thoracic Surgeons

Articles

Calcific Stenosis of the Porcine Heterograft

John J. Lamberti, M.D.*, Bruce H. Wainer, M.D., Kenneth A. Fisher, M.D., Harischandra B. Karunaratne, M.D., Jafar Al-Sadir, M.D.

From the Departments of Pathology, Medicine, and Surgery, the University of Chicago, Pritzker School of Medicine, 950 E 59th St, Chicago, IL

Accepted for publication November 13, 1978.

* Address reprint requests to Dr. Lamberti, 7920 Frost St, Suite 304, San Diego, CA 92123

We have encountered two cases of late calcification of the porcine heterograft. A patient in chronic renal failure died of sepsis and endocarditis fifteen months after replacement of the mitral and tricuspid valves. At postmortem examination, both heterograft valves exhibited severe calcification and thrombosis. A second patient with rheumatic heart disease and sickle cell disease underwent mitral valve replacement for severe regurgitation. Thirty months later, cardiac catheterization revealed prosthetic valve stenosis. The valve was replaced successfully, and the excised heterograft exhibited severe calcification with restriction of leaflet motion. Although calcification of the porcine heterograft is known to occur in patients with infection or disorders of calcium metabolism, dysfunction of the heterograft is rare in our experience.




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