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Ann Thorac Surg 1979;27:554-558
© 1979 The Society of Thoracic Surgeons

Articles

Myocardial Rupture: III. Chamber Pressure, Rate of Distention, and Ventricular Disruption in Isolated Hearts

Ross T. Lyon, B.A., James M. Levett, M.D., James M. Sheridan, B.S., Seymour Glagov, M.D., C.E. Anagnostopoulos, M.D.*

From the Departments of Surgery and Pathology, Pritzker School of Medicine, The University of Chicago, Chicago, IL

Accepted for publication December 22, 1978.

* Address reprint requests to Dr. Anagnostopoulos, 950 E 59th St, BH E313 Box 152, Chicago, IL 60637

We have developed an in vitro technique for producing myocardial rupture in lamb hearts, which relates tensile strength to a variety of conditions which can prevail in normal and infarcted human hearts. Retrograde perfusion of saline solution and inflation of the left ventricle was used to apply progressive stress to the left ventricular wall. Three separate sites of myocardial rupture were observed and occurred with the frequency of 54% at the papillary muscle, 30% at the interventricular septum, and 16% at the free wall of the left ventricle. The distribution and configuration of the experimental ruptures were similar to those usually noted as complications of human myocardial infarction. The mean rupturing pressure was 526 mm Hg in normal lamb hearts. Application of these techniques should ultimately provide data relevant to the diagnosis, prevention, and treatment of myocardial rupture.




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W. M. Park, C. P. Connery, J. S. Hochman, M. D. Tilson, and C. E. Anagnostopoulos
Successful repair of myocardial free wall rupture after thrombolytic therapy for acute infarction
Ann. Thorac. Surg., October 1, 2000; 70(4): 1345 - 1349.
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