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Ann Thorac Surg 1979;27:24-31
© 1979 The Society of Thoracic Surgeons

Articles

Effects of Pulsatile Perfusion Pressure and Storage on Hearts Preserved for 24 Hours under Hypothermia, for Transplantation

Luis H. Toledo-Pereyra, M.D., Ph.D.*, Manuel Chee, M.D., Richard C. Lillehei, M.D., Ph.D.

Department of Surgery, Section of Transplantation and Surgical Research, Henry Ford Hospital, Detroit, MI, and the Department of Surgery, University of Minnesota, Minneapolis, MN.

Accepted for publication July 6, 1978.

* Address reprint requests to Dr. Toledo-Pereyra, Department of Surgery, Section of Transplantation and Surgical Research, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202.

Canine hearts preserved for 24 hours under hypothermic pulsatile perfusion at a systolic pressure of 25 mm Hg had better perfusion and transplantation survival results than hearts perfused at 50 or 80 mm Hg. Also, hearts perfused at a systolic pressure of 25 mm Hg did better than simple hypothermically stored hearts or fresh allografts. These findings indicate that hearts are adequately perfused for 24 hours under hypothermia for transplantation at a systolic pressure of 25 mm Hg.




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