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The Annals of Thoracic Surgery, Vol 26, 586-589, Copyright © 1978 by The Society of Thoracic Surgeons

ARTICLES

Operation or indomethacin for the premature ductus

LH Edmunds Jr

Indomethacin constricts the patent ductus arteriosus in approximately 70% of premature infants, but temporarily inhibits synthesis of all prostaglandins. Early toxicity of indomethacin is not prohibitive, but the possibility of late neurological deficits is raised by results of laboratory experiments. As yet, no late toxic effects of indomethacin have been observed. However, this possibility and the low morbidity (less than 2%) and mortality (less than 2%) of surgical ligation of the patent ductus arteriosus in premature infants favor operation except in carefully controlled and limited clinical trials.




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ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
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Copyright © 1978 by The Society of Thoracic Surgeons.