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Ann Thorac Surg 1978;26:586-589
© 1978 The Society of Thoracic Surgeons

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Articles

Operation or Indomethacin for the Premature Ductus

Division of Cardiothoracic Surgery, the University of Pennsylvania and Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104

Indomethacin constricts the patent ductus arteriosus in approximately 70% of premature infants, but temporarily inhibits synthesis of all prostaglandins. Early toxicity of indomethacin is not prohibitive, but the possibility of Iate neurological deficits is raised by results of laboratory experiments. As yet, no late toxic effects of indomethacin have been observed. However, this possibility and the low morbidity (< 2%) and mortality (< 2%) of surgical ligation of the patent ductus arteriosus in premature infants favor operation except in carefully controlled and limited clinical trials.

This article has been cited by other articles:

				S. A. Wilkerson, J. Fleischaker, C. Mavroudis, and L. N. Cook Developmental Sequelae in Premature Infants Undergoing Ligation of Patent Ductus Arteriosus Ann. Thorac. Surg., June 1, 1985; 39(6): 541 - 546. [Abstract] [PDF]

				C. Mavroudis, L. N. Cook, J. W. Fleischaker, H. S. Nagaraj, R. J. Shott, W. R. Howe, and L. A. Gray Jr. Management of Patent Ductus Arteriosus in the Premature Infant: Indomethacin versus Ligation Ann. Thorac. Surg., November 1, 1983; 36(5): 561 - 566. [Abstract] [PDF]

				B. Brandt III, W. J. Marvin, J. L. Ehrenhaft, S. Heintz, and D. B. Doty Ligation of Patent Ductus Arteriosus in Premature Infants Ann. Thorac. Surg., August 1, 1981; 32(2): 167 - 172. [Abstract] [PDF]