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Ann Thorac Surg 1978;26:222-227
© 1978 The Society of Thoracic Surgeons

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Articles

Safety and Rationale for Continuation of Propranolol Therapy During Coronary Bypass Operation

Divisions of Cardiology and Thoracic Surgery, and the Division of Pharmaceutics, The Ohio State University, Columbus, OH

^* Address reprint requests to Dr. Boudoulas, Division of Cardiology, The Ohio State University Hospitals, 466 W Tenth Ave, Columbus, OH 43210

Thirty consecutive patients undergoing coronary bypass were studied. Oral propranolol therapy was maintained up to 4 to 10 hours before operation. Nineteen of the patients had a history of myocardial infarction (MI), 14 had hypoakinetic areas, and 8 had decreased ejection fraction indicating advanced coronary artery disease.

Twenty-four-hour urinary epinephrine and norepinephrine obtained the day before operation were markedly increased at 136 ± 12 µg per 24 hours (normal, 39 ± 4 µg, p < 0.01). There were 4 perioperative MIs (13%) and no deaths. Plasma propranolol 1 hour before operation was 43.3 ± 8 ng per milliliter, indicating good beta blockade. Propranolol was started within 24 hours postoperatively. There were no preoperative, intraoperative, or postoperative complications related to propranolol therapy. We conclude that because of markedly increased adrenergic tone the day before operation and transient hypersensitivity to adrenergic stimulation after withdrawal of propranolol, this agent should be continued through coronary bypass operation.

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