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Ann Thorac Surg 1978;26:54-61
© 1978 The Society of Thoracic Surgeons

Articles

Development of a Practical Membrane Lung System

W.C. Helton, M.D., F.W. Johnson, M.D., J.B. Howe, F.B. Freedman, Ph.D., W.G. Lindsay, M.D., D.M. Nicoloff, M.D., Ph.D.*

Department of Surgery, University of Minnesota Hospitals, and Sci-Med Life Systems, Inc, Minneapolis, MN

Accepted for publication December 19, 1977.

* Address reprint requests to Dr. Nicoloff, Box 280, University Hospitals, 412 Union St, SE, Minneapolis, MN 55455

The purpose of this study was to evaluate a compact, single-pump membrane oxygenator system designed for both short-term open-heart procedures and long-term extracorporeal support. Work was directed at developing a compatible, disposable venous reservoir, fabricating a compact mounting board, determining acceptable priming volumes, and establishing safe and effective modes of setup and operation. Ten adult baboons undergoing total cardiopulmonary autotransplantation as part of a separate study were operated on using a 1.5 m2 Kolobow spiral-coil membrane system. Blood gases, oxygen transfer, extracorporeal blood flows, priming volume, and setup times were determined. In addition, 3 infant and 6 adult human subjects undergoing cardiac operations in which spiral-coil membranes of various sizes were used were also similarly studied. The data and experience from these studies suggest that the spiral-coil membrane system utilized is safe and effective in procedures requiring short-term cardiopulmonary bypass.






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