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Ann Thorac Surg 1978;25:541-550
© 1978 The Society of Thoracic Surgeons

Articles

A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart)

G. Lionel Zumbro, Jr., M.D.*, Larry Tillman, Ph.D., Aubrey O. Bailey, III, Robert L. Treasure, M.D.

Cardiac Surgical Services, Brooke Army Medical Center, Fort Sam Houston, TX, and University Hospital, Augusta, GA

* Address reprint requests to Dr. Zumbro, 1467 Harper St, Augusta, GA 30902

Ischemic contracture of the left ventricle ("stone heart") was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly.






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Copyright © 1978 by The Society of Thoracic Surgeons.