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The Annals of Thoracic Surgery, Vol 25, 510-515, Copyright © 1978 by The Society of Thoracic Surgeons

ARTICLES

"Total" therapy for small cell carcinoma of the lung

RE Johnson, HD Brereton and CH Kent

Seventy-one consecutive patients with small cell carcinoma of the lung were treated with an integrated approach between November, 1974, and May, 1977. The regimen included radiotherapy to the primary site, relatively brief (6 to 12 weeks) although intensive chemotherapy, and prophylactic cranial irradiation. Complete responses were achieved in 75% and 40% of patients with limited and extensive disease, respectively. Modest prolongation of survival (median, 10 months) was realized by patients with extensive disease, but prolonged relapse-free survival was not observed. In contrast, one-half of the patients with limited disease who achieved a complete response have remained clinically free of disease without further treatment for a mean of 18 months (range, 6 to 33 months). Since all relapses to date have been noted within the first year following cessation of treatment, this experience suggests there may be a potential for cure in those survivors who are now relapse free for intervals exceeding two years.


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D. H. Johnson
"The Guard Dies, It Does Not Surrender!" Progress in the Management of Small-Cell Lung Cancer?
J. Clin. Oncol., December 15, 2002; 20(24): 4618 - 4620.
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Copyright © 1978 by The Society of Thoracic Surgeons.