ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Alan Peterson
Marvin M. Kirsh
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peterson, A.
Right arrow Articles by Kirsh, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peterson, A.
Right arrow Articles by Kirsh, M. M.

Ann Thorac Surg 1978;25:340-345
© 1978 The Society of Thoracic Surgeons

Articles

The Effect of Glucagon in Animals on Chronic Propranolol Therapy

Alan Peterson, M.D., Benedict Lucchesi, M.D. Ph.D., Marvin M. Kirsh, M.D.*

Department of Surgery, Section of Thoracic Surgery, and the Department of Pharmacology, the University of Michigan Medical Center, Ann Arbor, MI.

Accepted for publication October 17, 1977.

* Address reprint requests to Dr. Kirsh, C7175 University Hospital, Ann Arbor, MI 48109

Eleven adult mongrel dogs were divided into two groups. Group 1 animals served as controls and Group 2 received propranolol (6 mg/kg/ day) orally in divided doses for 15 to 21 days. Prior to cardiopulmonary bypass, cardiac output, first derivative of left ventricular pressure (dp/dt), peak systolic pressure, heart rate, and central venous pressure were recorded. The animals were then placed on cardiopulmonary bypass and subjected to 30 minutes of global ischemia at the myocardial temperature of 32°C.

Following cessation of cardiopulmonary bypass the baseline studies were repeated. In Group 2 animals following the repeat studies, glucagon was administered at a rate of 0.13 µg/kg/min. The cardiac index and dp/dt were decreased by 43.3% (p < 0.001) and 40.5% (p < 0.001) in comparison to Group 1 animals. In Group 2 dogs, after bypass and glucagon infusion, cardiac index increased by 38% (p < 0.02), dp/dt rose by 78% (p < 0.05), and peak systolic pressure increased by 24.8% (p < 0.05).






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1978 by The Society of Thoracic Surgeons.