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Ann Thorac Surg 1978;25:117-121
© 1978 The Society of Thoracic Surgeons

Articles

Myocardial Revascularization in Patients Receiving Long-Term Propranolol Therapy

Marvin M. Kirsh, M.D.*, Douglas M. Behrendt, M.D., A. Peter Jackson, M.D., Prakash Dhadphale, M.D., Siray Alseri, M.D., James Brymer, M.D., Mark B. Orringer, M.D., Herbert Sloan, M.D.

Department of Surgery, Section of Thoracic Surgery, the Department of Anesthesiology, and the Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, MI.

Accepted for publication August 22, 1977.

* Address reprint requests to Dr. Kirsh, Section of Thoracic Surgery, C7163 Outpatient Building, Ann Arbor, MI 48109

Twenty-seven patients receiving long-term propranolol therapy underwent myocardial revascularization to relieve stable or unstable angina. The patients were randomly divided into two groups, one (Group 1) in which propranolol was discontinued 48 hours prior to operation and one (Group 2) in which patients received a final dose of propranolol 1 to 2 hours prior to operation.

Several physiological variables were compared, and there was no statistically significant difference between the groups except for a slower pulse rate in Group 2 patients. Although the patients in Group 1 showed a greater frequency of hypertension before bypass, the incidence of postoperative complications and perioperative myocardial infarction was the same for both groups.

The findings of this study indicate that myocardial revascularization is safe even if propranolol is administered up to 1 or 2 hours before operation.




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