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Ann Thorac Surg 1978;25:112-116
© 1978 The Society of Thoracic Surgeons

Articles

Sustained-Release Implants of Chemical Carcinogens in the Canine Tracheobronchial Tree

Kimito Matsumura, M.D., Edwin C. Shors, M.S., Paul C. Fu, Ph.D., Arthur H. Cohen, M.D., John R. Benfield, M.D.*

Departments of Surgery and Pathology, Harbor General Hospital Campus of the UCLA School of Medicine, Torrance, CA.

Accepted for publication July 22, 1977.

* Address reprint requests to Dr. Benfield, Professional Staff Association of Harbor General Hospital, 1124 W Carson St, Torrance, CA 90502

A proved carcinogen, benzo[a]pyrene (BP), was incorporated into liquid silicone rubber polymer which was then vulcanized into solid form. Discs of BP polymer containing 9.05 to 12.12% BP were sutured into the trachea and right main bronchi of 10 dogs which were observed for 3 to 8 months. The discs were either in contact with the endobronchial surface of the mucosa or placed into submucosal pockets. All discs that were implanted submucosally remain in place. Only 2 discs implanted by the fixation method were extruded. The pocket implants of BP polymer caused ulceration and erosion of the mucosa; these changes did not occur from discs of polymer without carcinogen. To date these implants have induced squamous metaplasia with atypical changes. A method for sustained-release implantation of carcinogens in the canine tracheobronchial tree has been developed.




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A Clinically Relevant Canine Lung Cancer Model
Ann. Thorac. Surg., December 1, 1981; 32(6): 592 - 601.
[Abstract] [PDF]


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