HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Selecky, P. A. Articles by Lippmann, M. Search for Related Content PubMed PubMed Citation Articles by Selecky, P. A. Articles by Lippmann, M.

The Annals of Thoracic Surgery, Vol 24, 451-461, Copyright © 1977 by The Society of Thoracic Surgeons

ARTICLES

The clinical and physiological effect of whole-lung lavage in pulmonary alveolar proteinosis: a ten-year experience

PA Selecky, K Wasserman, JR Benfield and M Lippmann

We have utilized whole-lung lavage in the successful treatment of 18 patients with pulmonary alveolar proteinosis. Our ten-year experience includes serial evaluations of patients with disabling lung dysfunction who had a total of 49 whole-lung lavages under general anesthesia. Clinical and physiological responses were documented both before and after each lavage. There were no complications or deaths. All patients were radiographically, physiologically, and symptomatically improved within hours after the procedures. Five patients required from two to four repeat lavages one to three years later. The treatment of this disorder has included a wide variety of techniques. We attribute our results to the use of a lung lavage technique that includes: (1) unilateral whole-lung lavages at two to three day intervals; (2) isotonic saline as the lavage solution; (3) use of a mechanical chest percussor during lavage; and (4) measuring the total thoracic compliance of each side in the immediate postlavage period as a guide for extubation. We conclude that whole-lung lavage is a safe, highly effective, repetitively applicable treatment for pulmonary alveolar proteinosis.

This article has been cited by other articles:

				O C Ioachimescu and M S Kavuru Pulmonary alveolar proteinosis Chronic Respiratory Disease, July 1, 2006; 3(3): 149 - 159. [Abstract] [PDF]

				C. Morgan The benefits of whole lung lavage in pulmonary alveolar proteinosis Eur. Respir. J., April 1, 2004; 23(4): 503 - 505. [Full Text] [PDF]

				M. Beccaria, M. Luisetti, G. Rodi, A. Corsico, M.C. Zoia, S. Colato, P. Pochetti, A. Braschi, E. Pozzi, and I. Cerveri Long-term durable benefit after whole lung lavage in pulmonary alveolar proteinosis Eur. Respir. J., April 1, 2004; 23(4): 526 - 531. [Abstract] [Full Text] [PDF]

				B. C. Trapnell, J. A. Whitsett, and K. Nakata Pulmonary Alveolar Proteinosis N. Engl. J. Med., December 25, 2003; 349(26): 2527 - 2539. [Full Text] [PDF]

				J. F. Seymour and J. J. Presneill Pulmonary Alveolar Proteinosis: Progress in the First 44 Years Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 215 - 235. [Abstract] [Full Text] [PDF]

				C.-W. Chou, F.-C. Lin, S.-M. Tung, R.-D. Liou, and S.-C. Chang Diagnosis of Pulmonary Alveolar Proteinosis: Usefulness of Papanicolaou-Stained Smears of Bronchoalveolar Lavage Fluid Arch Intern Med, February 26, 2001; 161(4): 562 - 566. [Abstract] [Full Text] [PDF]

				J. F. SEYMOUR, J. J. PRESNEILL, O. D. SCHOCH, G. H. DOWNIE, P. E. MOORE, I. R. DOYLE, J. M. VINCENT, K. NAKATA, T. KITAMURA, D. LANGTON, et al. Therapeutic Efficacy of Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Idiopathic Acquired Alveolar Proteinosis Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 524 - 531. [Abstract] [Full Text]

				M. S. CARRAWAY, A. J. GHIO, J. D. CARTER, and C. A. PIANTADOSI Detection of Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Pulmonary Alveolar Proteinosis Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1294 - 1299. [Abstract] [Full Text]

				I. R. DOYLE, K. G. DAVIDSON, H. A. BARR, T. E. NICHOLAS, K. PAYNE, and J. PFITZNER Quantity and Structure of Surfactant Proteins Vary Among Patients with Alveolar Proteinosis Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 658 - 664. [Abstract] [Full Text]