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Ann Thorac Surg 1977;24:284-288
© 1977 The Society of Thoracic Surgeons

Articles

Chronic Interstitial Pneumonitis with Fibrosis after Long-Term Therapy with Nitrofurantoin

Simon J. Simonian, M.D., Edwin J. Kroeker, M.D., David P. Boyd, M.D.*

From the Departments of Medicine and Surgery, Lahey Clinic Foundation, Boston, MA

Accepted for publication January 6, 1977.

* Address reprint requests to Dr. Boyd, Department of Surgery, Lahey Clinic Foundation, 605 Commonwealth Ave, Boston, MA 02215

Nitrofurantoin has been used widely as a urinary antiseptic. That it may cause pulmonary infiltration, and even fibrosis, has not been recognized universally. The literature contains 24 cases of interstitial pneumonitis with fibrosis. The results of treatment are summarized, and a new case is reported in detail.




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