HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tandon, A. P. Articles by Ionescu, M. I. Search for Related Content PubMed PubMed Citation Articles by Tandon, A. P. Articles by Ionescu, M. I.

Ann Thorac Surg 1977;24:149-155
© 1977 The Society of Thoracic Surgeons

---

Articles

Sequential Hemodynamic Studies in Patients Having Aortic Valve Replacement with the Ionescu-Shiley Pericardial Xenograft

Departments of Cardiology and Cardiothoracic Surgery, The General Infirmary, Leeds, England

Accepted for publication February 24, 1977.

^* Address reprint requests to Dr. Ionescu, Department of Cardiothoracic Surgery, The General Infirmary, Leeds LS1 3EX, England

Sequential hemodynamic studies were performed in 13 patients having aortic valve replacement with glutaraldehyde-stabilized pericardial xenografts. The investigation done preoperatively was repeated twice in all patients at mean intervals of 9.9 and 42.2 months following valve replacement. Annulus diameters of the valves were 19, 23, and 25 mm.

Between the preoperative and the first postoperative investigation there was a significant increase in cardiac index (p < 0.05) and a significant reduction in both pulmonary wedge and left ventricular end-diastolic pressures (p < 0.01). At the first postoperative study the mean ejection systolic gradient across the three sizes of aortic pericardial xenograft was 7, 15.7, and 8.4 mm Hg at rest and 10, 19.6, and 13.7 mm Hg on exercise, respectively. The corresponding surface areas of the three valve sizes were 1.1, 1.5, and 1.62 cm² at rest and 1.4, 2.1, and 2.03 cm² on exercise. There was no significant change in any of these measurements between the first and the second postoperative study. The results have shown considerable postoperative hemodynamic improvement, insignificant transvalvular pressure gradients, and maintenance of the functional integrity of the pericardial xenograft up to 56 months following valve insertion.

This article has been cited by other articles:

				M. P. Brais, J. P. Bedard, W. Goldstein, A. Koshal, and W. J. Keon Ionescu-Shiley Pericardial Xenografts: Follow-up of Up to 6 Years Ann. Thorac. Surg., February 1, 1985; 39(2): 105 - 111. [Abstract] [PDF]

				J. M. Smith III, D. A. Cooley, D. A. Ott, W. Ferreira, and G. J. Reul Jr. Aortic Valve Replacement in Preteenage Children Ann. Thorac. Surg., June 1, 1980; 29(6): 512 - 518. [Abstract] [PDF]

				M. I. Ionescu, A. P. Tandon, and F. J. Macartney Long-Term Sequential Hemodynamic Evaluation of Right Ventricular Outflow Tract Reconstruction Using a Valve Mechanism Ann. Thorac. Surg., May 1, 1979; 27(5): 426 - 434. [Abstract] [PDF]